averagedoc
Greenlighter
- Joined
- Aug 22, 2015
- Messages
- 4
I read through the Loperamide mega thread. I am very concerned for the safety of the community.
I researched this a bit and I want you all to know that there is absolutely no doubt that high dose loperamide is deadly due to heart toxicity.
There have been several recent deaths reported (all over the country) in the medical literature due to loperamide induced heart conduction problems in the last year.....more and more this year are having this cardiac effect. Probably due to dissemination of information on forums like this leading to more high dose use. Several people have been found dead at home with no cause other than massive blood levels of loperamide. In addition, patients who have survived have come close to death in the hospital.
There is no treatment other than time in the hospital off the drug, and shocking your heart when it goes into ventricular tachycardia or other rhythm disorders....apparently many people never made it to the hospital....at least 3 deaths at home that I found in the literature....and many patients with near death events requiring hospitalization and intensive care. There is no way to reverse the toxicity except to wait it out...no reversal drug for the cardiac toxic effect. This is not an opiate effect on the heart, it is a different aspect of the molecule that blocks ion channels in the heart...this effect can also be seen with high dose methadone, which is similar in structure to lope.
Most of the reports seem to indicate DAILY use of loperamide at 100mg or more. However, this does not mean that lower doses are safe. Obviously the normal doses are very safe, but anything above that and you are risking sudden death.
The LONGER you take it, the higher the risk...one report showed that the patient only started to have significant problems after 9 months of use...daily use will build up the dose in your system and the toxicity is more likely.
Please do not take high dose loperamide!!!!
You can easily die. These were all otherwise healthy young people.
Its clear that some individuals do get addicted to this drug for whatever reason. Im not here to argue about that. I believe it is euphoric to some people and not others.
I highly doubt its high is worth death or long hospitalization.
Its unpredictable who will get the cardiac effects, but clearly its not the exception, its very common.
If you MUST take this, please please heed this warning. Use as little as possible...NEVER USE 100mg or more. Do no exceed the max dose of 16mg a day.
Never take it two days in a row at any dose above the standard doses... there is no need anyway, the reports here suggest is holds WD for at least 2 days. Those who get high from it report it lasting 2-3 days on one dose.
Dont combine it with other drugs or medications.
FDA is getting these reports and I would anticipate some action such as limiting the quantity that can be sold (like pseudo?) or moving it to RX only.
But commercial interests from the manufacturers might limit this.....
I doubt it will be scheduled..Ive never heard of OTC direct to scheduled....
Sadly moving hydrocodone to C2 and making Kratom illegal will probably only move more people to Lope with resultant toxicity that could have been avoided with something apparently safer like Kratom.
If you are in WD, consider only low dose Kratom as a better legal alternative for WD or better yet, see a doctor....
There is no question in my MD mind....sadly Loperamide is a heart poison at the doses most need to get the "high" that they are looking for....
Just stick to the acceptable doses of 16mg a day or less and that has been shown to be safe and does not affect the heart.
Please be careful.
I researched this a bit and I want you all to know that there is absolutely no doubt that high dose loperamide is deadly due to heart toxicity.
There have been several recent deaths reported (all over the country) in the medical literature due to loperamide induced heart conduction problems in the last year.....more and more this year are having this cardiac effect. Probably due to dissemination of information on forums like this leading to more high dose use. Several people have been found dead at home with no cause other than massive blood levels of loperamide. In addition, patients who have survived have come close to death in the hospital.
There is no treatment other than time in the hospital off the drug, and shocking your heart when it goes into ventricular tachycardia or other rhythm disorders....apparently many people never made it to the hospital....at least 3 deaths at home that I found in the literature....and many patients with near death events requiring hospitalization and intensive care. There is no way to reverse the toxicity except to wait it out...no reversal drug for the cardiac toxic effect. This is not an opiate effect on the heart, it is a different aspect of the molecule that blocks ion channels in the heart...this effect can also be seen with high dose methadone, which is similar in structure to lope.
Most of the reports seem to indicate DAILY use of loperamide at 100mg or more. However, this does not mean that lower doses are safe. Obviously the normal doses are very safe, but anything above that and you are risking sudden death.
The LONGER you take it, the higher the risk...one report showed that the patient only started to have significant problems after 9 months of use...daily use will build up the dose in your system and the toxicity is more likely.
Please do not take high dose loperamide!!!!
You can easily die. These were all otherwise healthy young people.
Its clear that some individuals do get addicted to this drug for whatever reason. Im not here to argue about that. I believe it is euphoric to some people and not others.
I highly doubt its high is worth death or long hospitalization.
Its unpredictable who will get the cardiac effects, but clearly its not the exception, its very common.
If you MUST take this, please please heed this warning. Use as little as possible...NEVER USE 100mg or more. Do no exceed the max dose of 16mg a day.
Never take it two days in a row at any dose above the standard doses... there is no need anyway, the reports here suggest is holds WD for at least 2 days. Those who get high from it report it lasting 2-3 days on one dose.
Dont combine it with other drugs or medications.
FDA is getting these reports and I would anticipate some action such as limiting the quantity that can be sold (like pseudo?) or moving it to RX only.
But commercial interests from the manufacturers might limit this.....
I doubt it will be scheduled..Ive never heard of OTC direct to scheduled....
Sadly moving hydrocodone to C2 and making Kratom illegal will probably only move more people to Lope with resultant toxicity that could have been avoided with something apparently safer like Kratom.
If you are in WD, consider only low dose Kratom as a better legal alternative for WD or better yet, see a doctor....
There is no question in my MD mind....sadly Loperamide is a heart poison at the doses most need to get the "high" that they are looking for....
Just stick to the acceptable doses of 16mg a day or less and that has been shown to be safe and does not affect the heart.
Please be careful.
