Amu
Bluelighter
- Joined
- Feb 19, 2010
- Messages
- 205
How likely is it for a normal to high dosage of N-Acetyl Cysteine (NAC) of 1200 mg twice or thrice a day to block the properties of Ketamine, and if so, which ones? Dissociative? Bad After-Effects such as social withdrawal? How about the "fun" color / sound properties?
And lastly, the anti-depressant properties? I've researched NAC quite a bit, and it seems to be hard to pin down the effects. I'll quote wikipedia as it is fairly accurate in this case:
"Acetylcysteine serves as a prodrug to L-cysteine which is a precursor to the biologic antioxidant, glutathione and hence administration of acetylcysteine replenishes glutathione stores. L-cysteine also serves as a precursor to cystine which in turn serves as a substrate for the cystine-glutamate antiporter on astrocytes hence increasing glutamate release into the extracellular space.
This glutamate in turn acts on mGluR2/3 receptors, and at higher doses of acetylcysteine, mGluR5. Glutathione also modulates the NMDA receptor by acting at the redox site. Acetylcysteine also possesses some anti-inflammatory effects possibly via inhibiting NF-κB and modulating cytokine synthesis. It may also facilitate dopamine release in certain brain areas."
And lastly, the anti-depressant properties? I've researched NAC quite a bit, and it seems to be hard to pin down the effects. I'll quote wikipedia as it is fairly accurate in this case:
"Acetylcysteine serves as a prodrug to L-cysteine which is a precursor to the biologic antioxidant, glutathione and hence administration of acetylcysteine replenishes glutathione stores. L-cysteine also serves as a precursor to cystine which in turn serves as a substrate for the cystine-glutamate antiporter on astrocytes hence increasing glutamate release into the extracellular space.
This glutamate in turn acts on mGluR2/3 receptors, and at higher doses of acetylcysteine, mGluR5. Glutathione also modulates the NMDA receptor by acting at the redox site. Acetylcysteine also possesses some anti-inflammatory effects possibly via inhibiting NF-κB and modulating cytokine synthesis. It may also facilitate dopamine release in certain brain areas."