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Opioids Levomethadone vs regular Methadone?

B

Båtmannen

Bluelighter
Joined
Jan 18, 2015
Messages
280
Hello,

Levomethadone is now used as an alternative to racemic (?) Methadone.

The good part is that it has higher affinity/selectivity for the mu-opioid-receptor; the receptor responsible for the euphoria and good effects of Methadone.

The bad part is that it's a weaker NMDA-antagonist, meaning, theoretically, and this is coming from my mind so please correct me if I'm wrong, that the tolerance-increase will be more significant than with regular Methadone.


Has anyone tried levomethadone (as therapy, i e every day, not just once or so) and noticed any difference?


Best regards
 
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