EastCoast
Bluelighter
- Joined
- Jan 19, 2017
- Messages
- 133
As many if not all of you know about the "less is more" theory surrounding norbuprenorphine ..
but I get how there is a ceiling per say, and how taking suboxone in doses of 8mg + is a waste, because the scientific facts behind that make sense, but not so much with the less is more theory
now don't get me wrong I'm not denying that 2mg can bring or will bring the same effect as 16mg...BUT
how can less be MORE if the full agonist norbuprenorphine doesn't really, if at all, cross the BBB cuz of PGP...??
and even with that said wouldn't 4mg blow 2mg< out the water?? But I don't really know for sure? I just took about an hour ago a dose of 1.5 mg and though I feel a bit better from PAWS with slight euphoria , I don't feel a difference between this dose and let's say 4mg, so I do realize that a smaller dose can have the same effect, which I don't understand for the purpose of science since I'm taking less bupe, but it seems to be true
BUT the bigger question lays with how is it MORE?
P.S. Even if you DO cause the norbuprenorphine to cross the BBB fully and completely activate it with the help of other substances , where is the scientific backing that bupe still wouldn't fight to block the active norbupe trying to attach to the receptors?? I couldnt find one source.
I think this theory is interesting, and people seem to back it and I'm never one of those people to say what there feeling is placebo, but it truly doesn't make sense for the fact that norpube technically is not active? Or am I wrong? Idk... and if it was wouldn't bupe still do what it was meant to? Or no?
Im no doctor, that is why I'm asking you guys who might have a little more insight to educate me, and don't just look at the title and say because norbupe, I want to know how....
if your even one of those that truly believe "less is more"
Thanks - The best coast; The East Coast
but I get how there is a ceiling per say, and how taking suboxone in doses of 8mg + is a waste, because the scientific facts behind that make sense, but not so much with the less is more theory
now don't get me wrong I'm not denying that 2mg can bring or will bring the same effect as 16mg...BUT
how can less be MORE if the full agonist norbuprenorphine doesn't really, if at all, cross the BBB cuz of PGP...??
and even with that said wouldn't 4mg blow 2mg< out the water?? But I don't really know for sure? I just took about an hour ago a dose of 1.5 mg and though I feel a bit better from PAWS with slight euphoria , I don't feel a difference between this dose and let's say 4mg, so I do realize that a smaller dose can have the same effect, which I don't understand for the purpose of science since I'm taking less bupe, but it seems to be true
BUT the bigger question lays with how is it MORE?
P.S. Even if you DO cause the norbuprenorphine to cross the BBB fully and completely activate it with the help of other substances , where is the scientific backing that bupe still wouldn't fight to block the active norbupe trying to attach to the receptors?? I couldnt find one source.
I think this theory is interesting, and people seem to back it and I'm never one of those people to say what there feeling is placebo, but it truly doesn't make sense for the fact that norpube technically is not active? Or am I wrong? Idk... and if it was wouldn't bupe still do what it was meant to? Or no?
Im no doctor, that is why I'm asking you guys who might have a little more insight to educate me, and don't just look at the title and say because norbupe, I want to know how....
if your even one of those that truly believe "less is more"
Thanks - The best coast; The East Coast