Kratom potenator

[Wendy B]

How much vitamin c should I take with Kratom to help its effects?

 

[Snafu in the Void]

Vitamin C won't potentiate kratom. It may possibly attenuate tolerance or withdrawal if taken concurrently.

In any case there is no specific amount to take, the more the better.

 

[BK38]

Grapefruit juice

 

[thurston]

Black seed oil.

 

[JonnyDeath]

Turmeric; it's a blood thinner and will help correct the blood pressure changes it causes as well as give it an amazing boost.
I think it's also why I didn't build a tolerance to Kratom but twice before I used it, and those tolerances were easily fixed long before I added turmeric.
If you are taking it in herb form, the microwave, a coffee mug, some water and a lot of heat.
Most compounds boiling and burning point is far beyond what you can actually apply to most.
Caffeine's is way up there which is why the hotter you can brew coffee, the better the kick is.

 

[CmonYouShouldKnowBetter]

The only true potenitaor for kratom is NMDA antagonism. That and fat as mitragynine is lipophillic.

 

[CmonYouShouldKnowBetter]

Grapefruit juice

That would only inhibit CYP not making kratom stronger but possibly elongating the effects. However, it would take like 4 glasses to do so and would have to be drank half hour before the kratom dose

 

[Snafu in the Void]

That would only inhibit CYP not making kratom stronger but possibly elongating the effects. However, it would take like 4 glasses to do so and would have to be drank half hour before the kratom dose

Grapefruit could potentially reduce the opioid effect of kratom, since 7-OH-mitragynine conversion is mediated via 3a4... maybe.

Or it could just extend the duration, but it won't potentiate it.

 

[CmonYouShouldKnowBetter]

Grapefruit could potentially reduce the opioid effect of kratom, since 7-OH-mitragynine conversion is mediated via 3a4... maybe.

Or it could just extend the duration, but it won't potentiate it.

It would slow the breakdown/metabolization of it.

 

[Snafu in the Void]

It would slow the breakdown/metabolization of it.

Right, but mitragynine has multiple metabolism pathways in the liver, similar to codeine. Inhibiting 3a4 may cause preference for the other pathways and create less 7-OH.

 

[CmonYouShouldKnowBetter]

Right, but mitragynine has multiple metabolism pathways in the liver, similar to codeine. Inhibiting 3a4 may cause preference for the other pathways and create less 7-OH.

Interesting! I've never considered this, obviously. Still - am I wrong that you would have to drink a fuck ton of it anyway?

 

[Snafu in the Void]

Still - am I wrong that you would have to drink a fuck ton of it anyway?

It's not really about how much you drink, but how long. 1 glass of fresh squeezed juice works, but it doesn't really start inhibiting enzymes until about 4-7 days of drinking the juice daily.

Most people seem to believe you can drink it 30 minutes before dosing, but it doesn't work like that.

 

[Lil'LinaptkSix]

and fat

I do try to get some fattt food with most everything I use. All legit.
But yeah that v c or any other acidic chaser or add-on is good.
I use lemon honey cough drops after induction (tea) seems to work ok. Maybe all in my head.