That would only inhibit CYP not making kratom stronger but possibly elongating the effects. However, it would take like 4 glasses to do so and would have to be drank half hour before the kratom doseGrapefruit juice
Grapefruit could potentially reduce the opioid effect of kratom, since 7-OH-mitragynine conversion is mediated via 3a4... maybe.That would only inhibit CYP not making kratom stronger but possibly elongating the effects. However, it would take like 4 glasses to do so and would have to be drank half hour before the kratom dose
It would slow the breakdown/metabolization of it.Grapefruit could potentially reduce the opioid effect of kratom, since 7-OH-mitragynine conversion is mediated via 3a4... maybe.
Or it could just extend the duration, but it won't potentiate it.
Right, but mitragynine has multiple metabolism pathways in the liver, similar to codeine. Inhibiting 3a4 may cause preference for the other pathways and create less 7-OH.It would slow the breakdown/metabolization of it.
Interesting! I've never considered this, obviously. Still - am I wrong that you would have to drink a fuck ton of it anyway?Right, but mitragynine has multiple metabolism pathways in the liver, similar to codeine. Inhibiting 3a4 may cause preference for the other pathways and create less 7-OH.
It's not really about how much you drink, but how long. 1 glass of fresh squeezed juice works, but it doesn't really start inhibiting enzymes until about 4-7 days of drinking the juice daily.Still - am I wrong that you would have to drink a fuck ton of it anyway?
I do try to get some fattt food with most everything I use. All legit.and fat