There is no actual set amount that would push a person into overdose territory.
The LD 50 with a blood alcohol level of 0.05 would be exponentially lower. Never understimate drug synergy.While the LD 50 of Clonazepam from animals postulated into humans is astronomically high, it's the indirect occurrences like stairs, falls, electrocution, drowning, aspirating vomit, etc that seem to be just as problematic. Not that you couldn't have a bad reaction or be hypersensitive of course, but mix a downer with a fraction of that clonazepam and the odds of a bad outcome rise exponentially.
While the LD 50 of Clonazepam from animals postulated into humans is astronomically high, it's the indirect occurrences like stairs, falls, electrocution, drowning, aspirating vomit, etc that seem to be just as problematic. Not that you couldn't have a bad reaction or be hypersensitive of course, but mix a downer with a fraction of that clonazepam and the odds of a bad outcome rise exponentially.
The LD 50 with a blood alcohol level of 0.05 would be exponentially lower. Never understimate drug synergy.
The low incidence of respiratory depression with benzodiazepines, which differentiates it from barbiturates, is related to the low density of binding sites in the brainstem which houses the respiratory center.
https://www.ncbi.nlm.nih.gov/books/NBK482238/Benzodiazepines (BZDs) taken in toxic doses without other coingestants rarely cause a significant toxidrome. The classic presentation in patients with isolated benzodiazepine overdose will include central nervous system (CNS) depression with normal or near normal vital signs. Many patients will still be arousable and even provide a reliable history. Classic symptoms include slurred speech, ataxia, and altered mental status. Respiratory compromise is uncommon in isolated BZD ingestions, but if taken with coingestants such as ethanol or other drugs/medications, respiratory depression can be notable. Of clinical importance is that most intentional ingestions of benzodiazepines involve coingestants, the most common being ethanol, which can lead to substantial respiratory depression and airway compromise. The dose required to produce respiratory compromise is difficult to quantify and depends on multiple factors including dosage, tolerance, weight, age, coingestants, and even genetics. Patients with severe toxicity will present stuporous or comatose, and immediate airway management and mechanical ventilation may be required.
Is that true? I thought there definitely was.