Ketamine in all its uses is a good example of place, time & manner, set & setting, social expectations, maybe darker things like prejudice too -- it has many of the same effects as phencyclidine, but I took all sorts of it and I did not flip out, pluck out my eyeballs, destroy an automobile with my bare hands, run from the cops at 80 km/h on two broken legs and/or vault onto a roof from the ground, break six pairs of handcuffs and kill 10 cops or end up in the puzzle factory for 70 years -- and I am guessing a huge fraction of phencyclidine users have the same experience or similar.