Hello,
Many research studies have established that ketamine is likely one of the best antidepressants in the world, providing rapid, substantial relief for 70+% of treatment resistant patients who had failed to improve on many previous drug trials. The antidepressant effect is believed to be related to the NMDA receptor antagonism.
Is there reason to believe that the ketamine analog methoxetamine would be equally effective for treatment resistant depression? Both are NMDA receptor antagonists, but they are clearly different compounds with different effects.
I am very curious about this because I have suffered from treatment resistant depression for many years. Ketamine is not being offered by any local doctors for depression since it is not FDA approved for that use (I live in the US). Even though doctors in the US are allowed to prescribe any FDA approved drug for "off-label" uses, no doctors in the area where I live are doing this with ketamine.
Also, I think my MDMA use several years ago made my depression much worse. Could ketamine and/or methoxetamine help reverse mood problems related to MDMA use?
Thanks!
Norman
Many research studies have established that ketamine is likely one of the best antidepressants in the world, providing rapid, substantial relief for 70+% of treatment resistant patients who had failed to improve on many previous drug trials. The antidepressant effect is believed to be related to the NMDA receptor antagonism.
Is there reason to believe that the ketamine analog methoxetamine would be equally effective for treatment resistant depression? Both are NMDA receptor antagonists, but they are clearly different compounds with different effects.
I am very curious about this because I have suffered from treatment resistant depression for many years. Ketamine is not being offered by any local doctors for depression since it is not FDA approved for that use (I live in the US). Even though doctors in the US are allowed to prescribe any FDA approved drug for "off-label" uses, no doctors in the area where I live are doing this with ketamine.
Also, I think my MDMA use several years ago made my depression much worse. Could ketamine and/or methoxetamine help reverse mood problems related to MDMA use?
Thanks!
Norman