Ketamine ad Nicotine

[Phobos]

After a few months of abstinence from Ketamine, I recently used some again consuming about a half gram of Esketamine in 2 days.
During this abstinence period I took up vaping, and the effects of Nicotine significantly diminished compared to the beginning of my use as it can be expected due to tolerance.
Now, after consuming Ketamine again, I noticed that vaping produces significantly more effects, as if the Esketamine somehow reversed the tolerance I had overnight.

Does anyone have a similar experience or know of any research about this?

 

[Vastness]

Interesting! I do not have a similar experience, although I generally find that vaping nicotine negatively affects the ketamine experience in some way, I'm not sure why but when I have been nicotine addicted and ketamine using, it's like my experiences have a more anxious edge to them. I can quite easily not vape on ketamine, although I have to consciously decide not to prior to the experience, otherwise if I'm mildly nicotine dependent then I generally will. But honestly I didn't really notice any effects on nicotine tolerance one way or the other. I always find nicotine tolerance to be somewhat fleeting and unpredictable - that said - so it's possible that in the morning after a K-binging session my first vapes of the day produced a more pronounced effect, but if it did I didn't consider it especially memorable and I think this would have quickly faded as the day went on.

 

[Meth novice 79]

I don’t think the 2 are related bro.
Something else is going on

 

[Phobos]

I don’t think the 2 are related bro.
Something else is going on

I'm not saying that I am sure that it is related, but it is a known fact that some drugs can at least partially reverse tolerance for some other drugs very quickly.

 

[Nicomorphinist]

There is a theory that ketamine and its enantiomers could have a dextromethorphan-like effect on narcotics by slowing down, stopping, or slowly reversing tolerance, so perhaps it does it to cholinergics like nicotine, and/or potentiating the nicotine? Nicotine does interact with the NMDA system as do the other two drugs, and there has been research on using this property to make it easier to quit smoking, amongst other things:

Memantine Reversing Nicotine Tolerance - Research Summary - Khemcorp - Solutions for Autism, Social Anxiety, ADHD and Drug Tolerance

Article is work in progress. I guess since NMDA receptors have such a role to play in drug tolerance, it isn’t exactly surprising that they seen to attenuate tolerance for alot of other types of drugs as well. Daily treatment for 7 days with nicotine (0.4 mg/kg s.c.) produced tolerance to the...

www.khemcorp.com

The interactive effects of ketamine and nicotine on human cerebral blood flow

The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF).Following 2–4 h of nicotine abstinence, healthy chronic smokers participated in four sets of rCBF studies, H[2] [15] O ...

www.ncbi.nlm.nih.gov

NMDA Receptors Regulate Nicotine-Enhanced Brain Reward Function and Intravenous Nicotine Self-Administration: Role of the Ventral Tegmental Area and Central Nucleus of the Amygdala - Neuropsychopharmacology

Nicotine is considered an important component of tobacco responsible for the smoking habit in humans. Nicotine increases glutamate-mediated transmission throughout brain reward circuitries. This action of nicotine could potentially contribute to its intrinsic rewarding and reward-enhancing...

www.nature.com

The Role of NMDA Receptor Antagonists in Nicotine Tolerance, Sensitization, and Physical Dependence: A Preclinical Review

Nicotine, the primary psychoactive component of tobacco products, produces diverse neurophysiological, motivational, and behavioral effects through several brain regions and neurochemical pathways. Various neurotransmitter systems have been explored to ...

www.ncbi.nlm.nih.gov

Effects of nicotinic agonists on the NMDA receptor

The cholinergic nicotinic agonists (−)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced response…

www.sciencedirect.com

 

[vecktor]

There is no need to invoke NMDA as a mechanism, when it is well documented that ketamine metabolites in particular the dehydroketamine metabolites have nicotinic nAChR affinity both as agonist and antagonists depending on the nAChR subtype.