Lazarus Has A Point!
I am wondering where you got this information. Tramadol and codeine are not related. Also, a synthetic opiate can't possibility be related to a natural or semi-synthetic chemically (Hence the name "Synthetic" or "man-made").
Tramadol is a pro-drug synthetic opiate, meaning it must be metabolized before the mu agonist effect can occur.
Wow, talk about clever trolling by Unknown...
This is a useful old thread, and while reading through it, I saw this unacknowledged travesty where Unknown completely (and I think possibly intentionally) misinterprets StrawPipes useful post (Post #29 of this thread) regarding the molecular similarities between tramadol and codeine, and his/her very relevant claim that tramadol is not actually an opiate.
Unknown makes a huge leap in the quote above when suggesting that StrawPipes' observation of molecularly similarity between codeine and tramadol is really some kind of declaration that the two are "related". Unknown uses this blatant misinterpretation to further dismantle StrawPipes' credibility because synthetics CAN NEVER be "related" to organically derived compounds (an assertion that was never actually made). This troll-ish post de-railed the thread as it was beginning exploration of an important point.
Bringing me to the reason why I'd resurrect this 'never say die' thread, StrawPipes made a useful observation that is rarely heard amongst the vast multitude of often silly tramadol-related threads:
tramadol is not an opiate. Straw never suggested that tram and codeine are "related" (as in derived from the same molecular ancestors), just chemically similar.... as in a synthetic analog. A very basic concept that Unknown really does restate brilliantly later on in Post #48 as if it's his/her original idea. Laughable, man.....laughable.
One last comical point regarding real idiocy and total ignorance of chemical analogs is demonstrated quite nicely in the following quote from a portion of Post #34 by Unknown.
"Also, the wikipedia article says that tramadol is a synthetic stripped down version of codeine (oxymoron much?). That's proof alone that the person who wrote the article is an idiot."
Thank you, Unknown, for giving me a miniscule speck of Internet minutiae to dissect and enjoy on this cold wintry night.