If I dried the liquid out would I be left with a powdery residue? Similar to drying Ketamine out?
Both of them, as well as other 14-dihydromorphinones are white crystalline powders -- which need to be protected from light . . . the powder you get will probably be off-white, and solutions thereof turn from clear to an amber colour. There is not an appreciable change in potency according to all reports, but
something is happening so use opaque containers for everything and limit the time and intensity of light exposure.
Individual metabolism can affect some of the ratios, especially the morphine equianalgesia ratio:
oxymorphone HCl 10 mg IV = hydromorphone HCl 12.5 mg IV = morphine HCl 100 mg IV = oxymorphone HCl 100 mg PO = hydromorphone HCl 62.5 mg PO = morphine HCl 600 mg PO
The morphine to hydromorphone equianalgesia ratio is published as 8:1 -- this is the median and I think +3σ is 10:1 and -3σ is 4:1
The morphine to oxymorphone equianagesia ratio is published as 10:1 -- in my own experience and what I have seen of the literature, the variation is less
Duration of action: 4-6 hours morphine, 2-5 hydromorphone, 3-7 oxymorphone
Both drugs exhibit a moderate improvement in potency and bioavailability when taken SL versus PO: oxymorphone doubles BA to 20 per cent and trebles to 30 per cent via the buccal route; hydromorphone increases from 30-35 to 55 per cent, morphine increases some but to a lesser extent.
The 10:1 oxymorphone PO:IV ratio and 5:1 hydromorphone ratio do not seem to vary much, and compare to 6:1 for morphine
For all three drugs, there is no appreciable decline in potency in SC or IM administration versus IV but an increase of duration of action of 10-25 per cent
The PR to PO potency ratio for all three drugs is about 2:1 . . . morphine PR bioavailability 71 per cent, thought to be 80-88 for hydromorphone and oxymorphone
PO bioavailability: morphine 20-40 per cent, hydromorphone 30-35 per cent, oxymorphone 10 per cent
Intranasal potency and BA increases by a noticeable amount, and this is the case for all three but more marked with oxymorphone (BA more than quadruples, 10 to 4 per cent) and hydromorphone (30-35 per cent to 60-75 per cent)
Dose response curves: oxymorphone is steepest, then hydromorphone, then morphine
all three: 100 mg anhydrous HCl = 89.1 mg free base