Oh ok i got i understand it now thanks, Would a Dopamine reuptake inhibitor increase the duration of the dopamine being in the receptor from the codeine, if you take it after the codeine or before?
The pharmacology of opioids is way more complicated than "they make you release dopamine".
"Dopamine reuptake inhibitors" refers to stimulants like cocaine or methylphenidate (ritalin) that are euphoric on their own. Basically, if you had coke, you probably wouldn't be using it to "potentiate codeine", and the jitteryness from the ritalin would probably get in the way of the sedation ("the nod") that people are usually looking for when they're doing opioids. Not to mention that the coke/opioid combo ("speedball") has killed plenty of people because coke wears off much quicker than most opioids - people end up doing so much heroin that they stop breathing once the coke is no longer keeping their heart pumping.
Re: Using lyrica: The appropriate dose very much depends on your personal level of tolerance and individual brain chemistry. I've never used it recreationally, but just from using my prescribed dose over the years I have arrived at a point where I can take 600mg and barely feel it, while others will start getting dizzy and seeing double from their first 75mg pill.
I mean... pregabalin is a
relatively safe and effective potentiator for various downers and painkillers, but the "ideal" dose is really a very individual thing.
Benzodiazepines are more recreational than lyrica but they're also far more addictive; indeed, people generally have more problems overcoming a benzo addiction than a codeine or even heroin addiction, so I would be reeeal careful about using those (there's also the issue that while it is unlikely to overdose on benzodiazepines alone, they greatly increase the chances of OD'ing on opioids).
Regarding antihistamines... diphenhydramine has the advantage of being over-the-counter, but people have also been using various common prescription drugs like mirtazapine for the same purpose. Trazodone barely has any actual antihistaminergic effects, but feels very similar to one due to its combination of 5HT2x- and alpha1 antagonism.
Be aware though: While antihistamines aren't inherently addictive, a certain tolerance does build over time, which limits their useful dosage range somewhat - at high doses, such drugs often show anticholinergic effects, which leads to delirium (and not the
good kind of delirium, more like
"spiderspiderspiders everywhere!!1!" kind of delirium) and all sorts of fuckups in your autonomous nervous system (cardiac arrythmia, inability to shit or piss, hyperthermia...). Some antihistaminergic drugs also inhibit the reuptake of serotonin, which could also produce undesirable effects especially in people who are already on antidepressants. Others block adrenaline ("alpha 1") receptors, which may lead to a dangerous drop in blood pressure. And, as I said, too much dopamine antagonism is generally a bad thing too.
So, whatever you do, stay safe
