Ive been smoking roughly half ounce to a ounce a week for 3 years now deoends what drugs I do on the weekend. And ive been doing ecstasy and nangs most weekends for the last 8 months and just started trying acid. honestly ive felt abit anxious from speed based pills during the week after use but other then that no depression. Everyone is different though and drugs effect everyone differently. Best to just smoke however much you want/can afford and if it makes you depressed simply cut back to your sweet spot. Mines a half oz a week if I do anymore I find it makes me sluggish and grumpy.