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Misc is it possible to potentiate alcohol?

i find smoking a cig will kick in the alcohol strongly. but thats not really potentiation. drink on an empty stomach and drink quickly instead of spread out. that will lead to more 'euphoria' instead of just wastedness

btw 2000th post FTW
 
I do not recommend inhibiting enzymes, but for curiosities' sake alcohol is metabolized by CYP reductase and CYP2E1 (mostly) and a little less by CYP3A4 and CYP1A2.

Very good article on alcohol metabolism: http://pubs.niaaa.nih.gov/publications/arh23-1/40-54.pdf

More info on CYP2E1: http://en.wikipedia.org/wiki/CYP2E1

Inhibiting enzymes (and particularly 2E1) would potentiate it, possibly too much and also cause other side effects.

The only two majorly available 2E1 inhibitors are cimetidine and disulfiram (Antabuse). But those drugs will most likely make you barf from a small amount of alcohol. It is nearly impossible to titrate enzyme inhibition, so you will most likely inhibit too much and get alcohol poisoning.

Realistically, you would stand a better chance inhibiting 3A4 and 1A2, however the potentiating effect won't be as significant.

Check out my chart for a list of inhibitors. You can also find a link to it in the OD directory. http://img514.imageshack.us/img514/4571/cyp450yd7.gif

I just did a little research and cimetidine inhibits all the liver enzymes that you mentioned here so it seems like cimetidine would be the best thing to take to potentiate alcohol. I personally have tried using cimetidine to potentiate alcohol and it seemed to work...my liver seemed a little bit more sore than usual the next day though.
 
Alcohol and marijuana potentiate each other. The resulting effect seems to be overpowered by the marijuana though, so I would say that the marijuana is being potentiated by the alcohol more than the other way around.

However, if you are just looking to get as wasted as possible, a little but of each goes a long way.
 
zopiclone potentiates alcohol dramatically but not in a good way, zopiclone and topamax concurrent with a 5+ standard alcohol unit a day habit is a really good way to discover what the DT's feel like. You get a muted buzz, a hell of a craving in the morning, the meds stop working and then all of a sudden you have a clusterfuck of a chemical dependance.

I've had the DT's twice - what I thought were the DT's in the few years before that were just craving and withdrawal. The real DT's is pretty close to being in hell, with the insect hallucenations, seeing fibres in your skin, inkblot drawings, flashes of porno pictures, horror movies and just weird shit in your mind's eye, shaking and worrying that the next simple-partial seizure is going to start a cascade leading to a grand mal. 18 months of not too serious drinking combined with zopiclone and in the last lead-up clonazepam and then a family and medical tough love stance caused my first one. My second one came out of the blue just because I was 15lbs underweight after a bad flu, and I had done some xanax and zopiclone - no alcohol was involved. It was 5 days after I quit the benzos and I thought I tapered and next thing I know i'm tuned into the hell channel on my mind's eye and wired for sound. Alcohol is only manageable as a long term drug if you stick to just alcohol. I dont think pot does anything too serious beyond making you puke more and get the spins, but I have no real experience as I don't do pot.
 
thats how I got a peptic ulcer that took 3 years to get rid of. making alcohol hit harder on a depressive drinking binge is one thing, but now that i've grown up and out of my habits there are many, many things I learned about on the internet I regret, I have burns, cutting scars, nights in the drunk tank, some brain damage from head injuries directly because of alcohol, my stomach sphincter doesnt work properly anymore so its hard to eat - you really need to think about why exactly you want to do this.

On another note, the best way to potentiate alcohol is to have more of it. I did a few batches of "trashcan" which is a step up from pruno, and I learned a few important lessons. 1) Commercial yeast is very strong, if you don't kill it with metasulphite ($$$) you now have an incredibly vicious yeast in your body which will steal tons of nutrients, grow out of your mouth nose and butt and generally be a problem for years. and 2) Distilling is very dangerous, if you are desperate enough to be trolling the internet to figure out how to get even more fucked up and do even stupider things and then get even more fucked up to try and forget the stupid things you did, you probably should stick to commercially prepared products just so that someone else's mistakes get the liability instead of sobering up midlife and having only yourself to blame.

Be very careful with any kind of diuretic and alcohol - caffeine is a bad one. The one thing I learned early with power drinking was raw eggs in the morning - NAC is a bad idea, its concentrated cysteine which is the same thing in eggs, but it causes massive chelation of really critical nutrients if you take it in pill form. In raw egg form, especially with some grease - it will get your bile under control and keep your spleen in check. If you want to be a serious lush, you want a clean bile duct, a rich diet, an appendix, a spleen that works well and a stomach lining like iron. Iron will and weak stomachs result in puking up black bloody gunk that happens when something ruptures and mixes with bile. So painful even an IV shot of morphine doesn't take the edge off. Its just a sad irony of prohibitionist culture that anyone who is seriously interested in drugs has so many people kicking in artificial consequences that you end up doing shit like pruno and trashcan or snorting benedryl and eating nothing but ramen and crackers. Our culture really needs to change, but I doubt it will ever change in my dramatically shortened lifetime because of the mistakes I made.
 
anything done to potentiate benzos or alcohol is just going to make your withdrawal worse and your tolerance higher.

Something i've noticed specifically with klon users, is they start popping massive amounts of klon and drinking like crazy - even one night doing that as an occasional drinker can cause a pretty serious withdrawal syndrome a couple of days later.

I had a night out after I had quit my druggie ways, this was a few years back - and I saw all the kids rolling these massive joints and waving them around, showing off how much they can consume. The reality is, to be a true hedonist you want to take as little as possible and wait to see the effect, not to show off how much you can take without dying. Thats how you end up never getting invited out and get like me, I did so much drugs and booze that now that i'm sober i'm constantly anxious and I get virtually no rewards from any basic life events. Its a very fast ride to being a full time career junkie supporting a massive habit keeping the sicks away by trying to massively potentiate things. Potentiators usually work by throwing off some part of your metabolism and that will only just make it harder to recover. When I was a hardcore ketamine user I came across a post where a guy said an ounce had lasted him 6 years - that blew my mind, but he said he just waited until he really needed some insight, did a saline shot (don't forget the salt, if you don't use salt your red blood cells explode) and would have a clean trip with a benzo to keep it from going bad, and then spend the rest of the evening meditating on what insight he had gained.

There are crazy partiers, there are career partiers and then there are the elusive breed of lifetime hedonists. Discipline is hard, but it becomes alot easier the first time you see a videotape of when you thought you were having a blast and everyone loves you and a few days later you can see how out of control you are and how everyone around you is terrified of a trainwreck they just hope doesn't come their way. I remember one new years when I was in bed, woke up with an invite to a party with people I didn't know well, I showed up and power drank their open bar, already on zopiclone and clonazepam, fell off a porch, they couldn't get a cab because it was new years and two very large football players had to wait to sober up to drag me into their car and dump me on my lawn. I don't remember any of it but i'll never forget the email I got catching me up on what I did while I was "potentiating"
 
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