Firstly, it will take at least 100mg of Oxycodone considering current tolerance to start a decent nod. Many potentiators have been tried, and the best results were experienced with the use of Promethazine or Butalbital until recently when Milk Thistle was used.
According to a wide variety of sources, oral Milk Thistle inhibits Cytochrome P-450 3A4 and others by up to nearly 100% depending on amount ingested. I assume this is why potentiation of Oxycodone has been experienced.
Anyways, due to the consumption of various medications, periodic supplementation with Milk Thistle was decided upon to help liver health. Taking 400mg Milk Thistle Standardized 80% Extract 45 minutes before oral consumption of 50mg Oxycodone resulted in effects similar to what would be expected if 100mg Oxcodone was taken. None of the many potentiators previously tried comes remotely close to this level of potentiation.
Has anyone else experienced or heard of this? The reports about Milk Thistle in regards to opiate potentiation are few and far between. It seems that if such extreme/quality results as mentioned above are normal, more reports about Milk Thistle would be around bluelight and the greater internet. Is it truly unusually odd for such radical potentiation effects as described above to be experienced?
Thoughts/Comments/Whatever anyone?
WARNING: If anyone attempts potentiation with Milk Thistle, I recommend using Milk Thistle ONLY to potentiate opioid medications that are NOT combined with other substances (i.e APAP).
EDIT: Please note, I take an enhanced version of Milk Thistle extract which contains soy phospholipids which increase bioavailability of Silymarin. Regular Milk Thistle products and most extracts do not have this.
According to a wide variety of sources, oral Milk Thistle inhibits Cytochrome P-450 3A4 and others by up to nearly 100% depending on amount ingested. I assume this is why potentiation of Oxycodone has been experienced.
Anyways, due to the consumption of various medications, periodic supplementation with Milk Thistle was decided upon to help liver health. Taking 400mg Milk Thistle Standardized 80% Extract 45 minutes before oral consumption of 50mg Oxycodone resulted in effects similar to what would be expected if 100mg Oxcodone was taken. None of the many potentiators previously tried comes remotely close to this level of potentiation.
Has anyone else experienced or heard of this? The reports about Milk Thistle in regards to opiate potentiation are few and far between. It seems that if such extreme/quality results as mentioned above are normal, more reports about Milk Thistle would be around bluelight and the greater internet. Is it truly unusually odd for such radical potentiation effects as described above to be experienced?
Thoughts/Comments/Whatever anyone?
WARNING: If anyone attempts potentiation with Milk Thistle, I recommend using Milk Thistle ONLY to potentiate opioid medications that are NOT combined with other substances (i.e APAP).
EDIT: Please note, I take an enhanced version of Milk Thistle extract which contains soy phospholipids which increase bioavailability of Silymarin. Regular Milk Thistle products and most extracts do not have this.
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