I really wouldn't bother injecting Ambien CRs, because normal Ambien tablets are easily available and are definately a better choice for IV'ing, than those CRs.
i believe that wasnt the point of the question;
she stated she DID have cr's and what should be done with those;
considering i just spent a few hours trying to slam myself, i would say no it is pretty much impossible;
i washed by hand the first coating off, which leaves you with an almost half and half pill, one side white and they other pinkish;
first tried to just grind and add water, no dice;
not even the most vehement techniques will crush this badboys, they just goo up;
then, i tried scraping off most of the pink side as it seemed more gel-like, same deal, gooed up;
then i tried to just scrape tiny bits of white off at a time, also goo;
i ended up drinking the goo out of the spoon i was using, it tasted meh;
on a brighter (somewhat) note, the generic ambien, zolpidem is fairly easy to dissolve in water with no heat necessary, i just spent about 3 hours banging away on like maybe 10 of the small ones, i have pretty high tolerance for most everything but i enjoyed the feeling, comes on with a slight rush and i guess you could go to sleep, but after fighting with my veins for so long and so many shots, i was up and feeling a little psychotic/creative, so i did an awesome photoshoot with some limited props and lighting which i hadnt had the energy to do in days;
side note, there are apparently studies of this stuff having positive effects on some combination of either depressed/baboons/labrats or possibly all three;
just google about it;
not for the faint of heart and MOST DEFINITELY not for first time IV users;
it will take some ------>>>>>>>>tedious work to filter properly<<<<<-----------
btw this is all a hypothetical situation as i personally would never do drugs