Ham-milton
Bluelighter
- Joined
- Jul 20, 2007
- Messages
- 5,746
and first-pass metabolism.
that's irrelevant when using IV.
protein binding isn't included in bioavailability calculations AFAIK.
and I've never seen water and lipid solubility included in any measurement either.
It's always been my understanding that drugs are administered and then blood levels are taken and figured from there. It's not the sum of a bunch of factors as you put it, though they are effecting in how bioavailable a drug is, they're not part of the measure, it's not a formula based upon these things.