JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,464
Basically - Venlafaxine induces p-glycoprotein, such to reduce indinavir levels by 30%
I attempting to determine Mianserin based p-glycoprotein inhibition or induction.
So - I haven't a notion, outside of reading something to the effect of values close to 1 mean no implication via P-GP.
But maybe ya'll know for sure?
For MIANSERIN:
I attempting to determine Mianserin based p-glycoprotein inhibition or induction.
So - I haven't a notion, outside of reading something to the effect of values close to 1 mean no implication via P-GP.
But maybe ya'll know for sure?
For MIANSERIN:
PROPERTY | VALUE | PROBABILITY |
---|
P-glycoprotein substrate | Substrate | 0.8676 |
P-glycoprotein inhibitor I | Inhibitor | 0.8198 |
P-glycoprotein inhibitor II | Non-inhibitor | 0.9067 |
So - can anyone tell me - what that means?
I get it's saying, to some degree inhibitor, to some degree a substrate - but given the values, are they significant?
I get it's saying, to some degree inhibitor, to some degree a substrate - but given the values, are they significant?
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