WSH
Bluelighter
- Joined
- Nov 30, 2012
- Messages
- 360
5-MeO-DMT is known to cause both very postive effects and also very negative effects (e.g. racing heart, trouble breathing, panic attacks).
I've read that the combination with MDMA does away with these negative effects.
Here are a couple of reports that I've found:
It is known 5-MeO-DMT is a potent 5-HT1a agonist (~8nM; serotonin: 1.6nM) and 5-MeO-DMT also induces stimulus control via 5-HT1A receptors:
The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors.
MDMA increases serotonin release and is an antidepressant and anxiolytic (I'm talking about acute effects, not the famous hangover)
5-HT1a autoreceptors decrease serotonin release and therefore they increase depression and panic.
My theory is that the negative 5-MeO-DMT effects are caused by the reduction of serotonin release because of 5-HT1a autoreceptor activation. The MDMA-induced increase of serotonin release cancels out 5-MeO-DMT's decrease, that's why there were no negative effects. 5-MeO-DMT then selectively stimulates postsynaptic 5-HT1a receptors, which would explain the positive effects.
Any comments?
I've read that the combination with MDMA does away with these negative effects.
Here are a couple of reports that I've found:
"The MDMA seemed to completely do away with the terror that MeO can sometimes cause... the combination seems to bring out the best of both and combine them into a very nice whole"
"We began with just a tiny eyeballed hit, maybe 5mgs at the most. As soon as I blew out my hit I felt an instant RELAXATION, totally opposite of my 5-MeO trips alone. My thought process nearly stopped and I felt GOOD. Really, really good, like the best I've ever felt. There were no side effects! No racing heart, no problems breathing, just a mellow yet intense bliss"
It is known 5-MeO-DMT is a potent 5-HT1a agonist (~8nM; serotonin: 1.6nM) and 5-MeO-DMT also induces stimulus control via 5-HT1A receptors:
The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors.
In rats trained with 5-MeO-DMT, pindolol and WAY-100635 both produced a significant degree of antagonism of stimulus control
MDMA increases serotonin release and is an antidepressant and anxiolytic (I'm talking about acute effects, not the famous hangover)
5-HT1a autoreceptors decrease serotonin release and therefore they increase depression and panic.
My theory is that the negative 5-MeO-DMT effects are caused by the reduction of serotonin release because of 5-HT1a autoreceptor activation. The MDMA-induced increase of serotonin release cancels out 5-MeO-DMT's decrease, that's why there were no negative effects. 5-MeO-DMT then selectively stimulates postsynaptic 5-HT1a receptors, which would explain the positive effects.
Any comments?