Hey,
I'm member in an Ibogaine group and a lot of people complain about insomnia after receiving a large dose of ibogaine (mostly for addiction treatment). The insomnia seems to last about 4-6 months depended on the dose, but is permanent in some cases.
My theory:
Ibogaine itself causes microglia activation, which is similar to inflammation (not sure about this, please correct if wrong).
If this is true, the slow release from ibogaine and it's metabolites from fatty tissues such as the brain itself could cause a chronic inflammatory state of the brain, which then affects the mood and sleep. Also some people reported about severe lethargy and depression weeks and months after ibogaine use, which could also be caused by inflammation.
The microglia activation may not cause noticeably effects in some people because they may have a healthy lifestyle that prevents negative effects, but especially former drug users in the most cases have a disturbed brain chemistry and altered metabolism/general health, which then may be further destabilized by the microglia activation.
It fits somehow because ibogaine respectively noribogaine is present in fatty tissues for months after a large dose and this laps with the symptoms that are described. (non confirmed, but ibogaine itself accumulates about 100x more in fat than in plasma and is metabolized quickly to noribogaine, therefore such a long release is thinkable)
In this case, NSAID's or other anti-inflammatory substances such as turmeric extracts or cannabinoids may bring release to the symptoms.
Another reason may just be the increased levels of different neurotransmitters by the active metabolite noribogaine, which is the main metabolite of ibogaine stored in fatty tissues. Then the reason would be non-inflammatory and the mentioned substances would not bring relieve (CBD maybe, but not because of the anti-inflammatory effects).
Any ideas to that?
Links:
http://www.bluelight.org/vb/threads/765945-Half-Life-of-Noribogaine
https://www.ncbi.nlm.nih.gov/pubmed/11085338
https://books.google.at/books?id=jP...page&q=ibogaine storage fatty tissues&f=false
I'm member in an Ibogaine group and a lot of people complain about insomnia after receiving a large dose of ibogaine (mostly for addiction treatment). The insomnia seems to last about 4-6 months depended on the dose, but is permanent in some cases.
My theory:
Ibogaine itself causes microglia activation, which is similar to inflammation (not sure about this, please correct if wrong).
If this is true, the slow release from ibogaine and it's metabolites from fatty tissues such as the brain itself could cause a chronic inflammatory state of the brain, which then affects the mood and sleep. Also some people reported about severe lethargy and depression weeks and months after ibogaine use, which could also be caused by inflammation.
The microglia activation may not cause noticeably effects in some people because they may have a healthy lifestyle that prevents negative effects, but especially former drug users in the most cases have a disturbed brain chemistry and altered metabolism/general health, which then may be further destabilized by the microglia activation.
It fits somehow because ibogaine respectively noribogaine is present in fatty tissues for months after a large dose and this laps with the symptoms that are described. (non confirmed, but ibogaine itself accumulates about 100x more in fat than in plasma and is metabolized quickly to noribogaine, therefore such a long release is thinkable)
In this case, NSAID's or other anti-inflammatory substances such as turmeric extracts or cannabinoids may bring release to the symptoms.
Another reason may just be the increased levels of different neurotransmitters by the active metabolite noribogaine, which is the main metabolite of ibogaine stored in fatty tissues. Then the reason would be non-inflammatory and the mentioned substances would not bring relieve (CBD maybe, but not because of the anti-inflammatory effects).
Any ideas to that?
Links:
http://www.bluelight.org/vb/threads/765945-Half-Life-of-Noribogaine
https://www.ncbi.nlm.nih.gov/pubmed/11085338
https://books.google.at/books?id=jP...page&q=ibogaine storage fatty tissues&f=false