Maybe i'm quite lucky, but I don't seem to get much in the way of comedowns from MDMA unless I take excessive amounts or take it multiple times within a week. That said, I do take low dose of an SSRI, so that may have an impact.
That said, if I abuse MDMA, I'll know about it. The comedown is very dose-dependant and I've found it to be exponential with increasing dose - the comedown of 500mg will be much more severe than that off taking 200mg (which I probably wouldn't notice unless very stressed).
I've found Piracetam also helps reduce many of the comedown effects from other substances, such as LSD (which gives me severe comedowns for some reason).
I've found Piracetam to have strong anti-depressant properties in me.
At any rate, I'd take any MDMA comedown on the chin, as I love the effects so much, that it is worth it, and accept that such a powerful experience will come at a price, though of course your tolerances may be different.