This is a question I'm curious about myself. Rilmazafone is interesting after I read about it in a thread on this other forum. (BTW a simple google search says it has an 8 hour duration of effect with a 70 hour half-life its water soluble its a prodrug so makes no difference. It was also used in a study in Japan to prevent waking up to pee in the middle of the night "Nocturia" which it worked well for that purpose)
New molecules reverse memory loss linked to depression, aging - posted in Brain Health: Date: February 14, 2019 Source: Centre for Addiction and Mental Health Summary: New therapeutic molecules show promise in reversing the memory loss linked to depression...
www.longecity.org
Specifically they are trying to target the A5 receptor sub unit that
Rilmazafone is a prodrug (metabolized to) GL-II-73. It's commercially available, as linked above, but with warning below.
Unfortunately, GL-II-73, is not completely a5 selective. It hits a2, a3 at about 50% that of a5.
another person posted this:
- Ketamine
Upregulates GABRA5 (gene) expression with chronic dosing
This is a very indirect method - who knows what would happen
- Rilmazafone
https://www.mimaki-f...item_branch=001
Commercially available GABA a5 preferential PAM. Minor effects on a2, a3.
Based on the receptor effect profile, I liken this to something like Alprazolam (Xanax).
However, Alprazolam receptor affinity is reversed - prefers a2/a3 and less so on a5.