Opioids I cannot get high on codeine because I apparently lack the CYP2D6 enzyme

[TioW42]

I cannot get high on codeine because I apparently lack the CYP2D6 enzyme but will I be able to take other opiates. I took 256mg of codeine yesterday with no tolerance and I couldn't feel a thing not one bit and I mainly fall for placebo's but in this case I'm for sure it didn't effect me. Is there anyone here that can't get high on codeine but can get high on other opiates like oxycodone?

 

[Ksa]

If it's not a prodrug it's going to work. Oxycodone is not a prodrug. For example, tramadol is a prodrug. Not going to work. Dilaudid is not a prodrug, it's going to work.

Understood noob?

 

[TioW42]

If it's not a prodrug it's going to work. Oxycodone is not a prodrug. For example, tramadol is a prodrug. Not going to work. Dilaudid is not a prodrug, it's going to work.

Understood noob?

Oxycodone still uses CYP2D6 to metabolize to oxymorphone so doesn't that mean it's a pro drug?

 

[kleinerkiffer]

Oxycodone still uses CYP2D6 to metabolize to oxymorphone so doesn't that mean it's a pro drug?

No, because the quantity of oxymorphone is negligible.
Oxycodone is active on its own.

 

[shadowstryker]

No, because the quantity of oxymorphone is negligible.
Oxycodone is active on its own.

Pretty much this. Just like how hydrocodone metabolizes into hydromorphone too but is active on its own.

 

[weekend addiction]

Some people can't process codeine you noobs! (no offense) but its like 10 percent of the population IIRC.

 

[TioW42]

No, because the quantity of oxymorphone is negligible.
Oxycodone is active on its own.

Yeah but gram for gram oxymorphone is way more active

 

[iamstillalive]

Yeah but gram for gram oxymorphone is way more active

Yeah but the percentage of oxycodone converted to oxymorphone is <1mg IIRC. In other words negligible, noob.

 

[kleinerkiffer]

Yeah but the percentage of oxycodone converted to oxymorphone is <1mg IIRC. In other words negligible

Yep