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Opioids Hydro / Oxy Mix

S

SimplyTrinity

Bluelighter
Joined
Dec 26, 2020
Messages
51
I know the general advice is not to mix opioids. But is there a dangerous synergistic effect or is it just the total dosage I need to be careful about?

Specifically, been on 10mg Percocet for a couple of weeks. Down to my last 5/325 pill today, and wondering if it would be dangerous to supplement it with a 5/325 Vicodin? Would this be the same as 10/325 of either one, or is there a dangerous effect of mixing both?
 
I've personally never mixed the two but I know people that frequently mix oxycodone with hydromorphone in large quantities, like eating an OCD 80 then snorting a 24mg Hydromorph. You'll be ok
 
yeah I typically try to avoid mixing the two, but dealing with a limited supply and had to take the last of the oxy... and it wasn't quite enough

maybe I can take half of the 5/325 Vicodin and see how I react? But at that point, kind of splitting very small quantities.
 
Hydros & oxys are very similar. Most people find oxys to be a little stronger, more euphoric (I do), but they are classified as 1:1 in potency on most drug conversion charts. I've mixed them many times.

Half of a 5/325? Why bother taking it at all? I can't imagine feeling that at all unless one has zero tolerance.

And beware of 5/325s in general. That's a lot of acetaminophen with very little opioid payoff. Easy to take too many and get toxic amounts of acetaminophen.
 
Thx for the info

I’m only taking max 3 or 4 of these pills in a day (often less). I assume that’s fairly safe on the acetaminophen toxicity scale? 2 extra strength tylonel is 1000mg a pop and then people are often taking that twice a day right?
 
SimplyTrinity said:
Thx for the info

I’m only taking max 3 or 4 of these pills in a day (often less). I assume that’s fairly safe on the acetaminophen toxicity scale? 2 extra strength tylonel is 1000mg a pop and then people are often taking that twice a day right?
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Yeah, they do but they shouldn't-- at least not every day. 4000mg is considered the maximum to be taken in a day-- and some sources say 3000mg.
But that's only for every now&then. Daily use really needs to stay under 2000. And definitely avoid alcohol while taking acetaminophen. Your liver will thank you.
 
Thanks thanks

Yes, one benefit of opioids is it completely kills any desire for alcohol, at least for me.

Will stay under 2000mg per day for safety. I plan on being off them in a couple of days anyway, so it would have been 2 weeks of sustained use then a vacation from them
 
nznity said:
Yesos, I agree with u. I've barely had a drink in the last 7 months taking morphine errday.
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I still want to drink every single day. I'm not an alcoholic and never have been, I just like the flavor and the ritual of making a cocktail or opening a bottle of something and pouring it into a glass. Sometimes I'll just have a little 2 oz glass of wine
 
Reuben The Sand Witch said:
I still want to drink every single day. I'm not an alcoholic and never have been, I just like the flavor and the ritual of making a cocktail or opening a bottle of something and pouring it into a glass. Sometimes I'll just have a little 2 oz glass of wine
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I'd rather take some benzos pregabalin and a shot of 100mg. And a cigarette to nod off while the rush is fading away.
 
Ask your doc for Oxy-IR 5/10/20mg tablets…..only API is Oxycodone and a little excipients (no Tylenol)

If not available in your country ask for OxyContin Generic 10mg (you can pulverized tablet into powder for IR)

OxyNEO / OP are garbage and avoid like the plague…..tell doc you spoke with your private insurance or you have no insurance and can’t afford name brand expensive brand……cheap generic OCD 10/20/40/80mg are like the original formulation, just pulverized into fine powder for IR 30min onset

Also, yes you can mix & combine any full mu-opioid receptor agonist under the sun, obviously taking under consideration your personal tolerance, and any other CNS depressants (benzodiazepine, Pregabalin, alcohol, GHB, etc)

Ketamine is a very safe disassociate anesthetic/NMDA antagonist…..increasing dopamine and activity at mu-opioid receptors ……modern battlefield injuries are treated with auto-injector pens (like an epi-pen) loaded with Morphine Sulphate & Ketamine HCL) when you leg is blown off from a land mine, in shock, after Medic applies a turnacate to stop blood loss, elevates remaining limb to further stop blood loss…..they’ll slam that auto-injector into your thigh and that spring loaded mechanism will pump in that god blessed POTENT AS F@CK cocktail of Morphine & Ketamine and you’ll be in another world (mentally)

Ketamine doesn’t impaire breathing / airway or heart rate (significantly) so isn’t dangerous to combine with a CNS depressants like Morphine

You can easily order online in B.C. Canada along with LSD-25, Psilocybin, Cannabis, MDMA (sketchy), but the CLEANEST LSD you’ll ever find, and pharmaceutical grade Ketamine hcl crystalline salts

Maybe have a little Stimulants on hand if you start to nod off and an emergency Narcan nasal spray…..but you’re on 10mg of Oxycodone so your tolerance is non existent…….messing with Dilaudid (Hydromorphone) and combining various potent opioids can put you in some untested waters
 
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Dextro .45 said:
Are you doc for Oxy-IR 5/10/20mg tablets…..only API is Oxycodone and a little excipients (no Tylenol)

If not available in your country ask for OxyContin Generic 10mg (you can pulverized tablet into powder for IR)

OxyNEO / OP are garbage and avoid like the plague…..tell doc you spoke with your private insurance or you have no insurance and can’t afford name brand expensive brand……cheap generic OCD 10/20/40/80mg are like the original formulation, just pulverized into fine powder for IR 30min onset
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I’m not sure of all the terminology you used, but I’ve only ever gotten prescribed the oxy with acetaminophen. First 5/325 then eventually 10/325. Never above that dosage.

Right now, I literally cannot find a single pain management doctor to even prescribe me that anyone. Not a single one finds opioids to have any medicinal use, despite the fact that with my herniated discs, I am literally in excruciating and debilitating pain for 2-3 weeks every 18 months, with nothing useful to kill the pain.

I’m left to beg and borrow from friends/family every 2 years for leftover pills, but this will eventually run out. And I refuse to ever buy anything off the street for all the reasons you don’t want to.

Anyway - what you’re saying sounds great but right now I can’t even get the less ideal option.
 
API is the Active Pharmaceutical Ingredient = Oxycodone

Excipients are inactive bulking / flow agents in the mechanical pill press assembly, MCC 101 Micro Crystalline Cellulose (plant fibres in super fine white powder) ….keeps the API from sticking the machinery’s pill press asssembly, also adding weight to the tablet so you can hold it lol

The API in a standard tablets would be Soooooo freaking tiny it would look like a small grain of table salt. The added excipients/bulking agents turn the tablet into a standard size Tylenol sized pill a patient can easily handle and swallow

In the average tablet…..95% of the entire mass is non-active/inert excipients…..5% or less is the valuable Active Pharmaceutical Ingredient/ API
 
Doctors are scared as F@CK to dispense “dangerous opioid narcotics” addictive evil drugs, a liability when a patient OD and their medical license is now in jeopardy as the FDA investigation follows …..to an average doctor, f@ck it….I don’t need that headache for some Joe Shmo’s Mickey Mouse pain….probably just lying to me to get some addictive evil Oxycodone

Fucking medical establishment and 60-70% of family physicians are relatively incompetent and lack the TRUE knowledge and experience of prescribing controlled substances like Opioid Narcotics

You MUST find a Pain Clinic close to your area who are specialists in prescribing opioids……..have them fax in a referral form to your family doc, they fill out the form and fax back with all your medical records, proof of your accident/surgery/etc……tell them the true story of your situation and you’re in daily serious pain that is dramatically effecting your daily routine, mobility, employment situation, etc.

You have been taking Oxycodone prior and has been a very effective medication for you, and you specifically requested the lowest possible dosage as you’re aware of their tolerance inducing nature, etc

You only take them as needed when pain flairs up and it’s severe pain effecting your quality of life

Request your Oxycodone 10mg XR daily as needed plus a single 5mg IR tablet for “breakthrough” pain which does happen frequently, every pain specialist is aware of this

ALSO……request an NSAID anti-inflammatory (Naproxen) with added GI protection ingredient as it can cause stomach issues, must take with a meal also

This will reassure the pain management specialist you’re not specifically seeking just an addictive narcotic opioid drug and you REALLY have serious pain and are serious about treating your condition, reducing your pain and living a productive active lifestyle …..as you’re entitled to as a human being in a first class nation with modern medicine

Opium usage dating back 3,000 years in ancient mesothelioma as a pain killer and recreational drug…..the name they gave it, directly translates into “plant of joy” lol

Opium poppy
Coca leaves
Cannabis
Ethanol
Psilocybin mushrooms

All dating back THOUSANDS of years …..courtesy of Mother Nature & God

These magical natural medicinal plants specifically binding to our mammalian CNS brains

late 1800’s the Tropane Alkaloid was isolated from the Coca leaf and refined into its water soluble hydrochloride salt….Cocaine HCL.

Opium poppy main alkaloid discovered Morphine, Codeine, theBaine, Papavier……then came Diamorphine (Heroin), Dilaudid (Hydromorphone) and the king of the freaking show Eukadol (Oxycodone)

Courteous of the Father Land……Germany and their brilliant pharmaceutical professionals

Best of luck mate……follow through, you NEED to be seen by a Professional Pain SPECIALIST. Period.

F@CK these shook weak little bitches, you’re standard run of the mill family physician

Cheers :)
 
Dextro .45 said:
Doctors are scared as F@CK to dispense “dangerous opioid narcotics” addictive evil drugs, a liability when a patient OD and their medical license is now in jeopardy as the FDA investigation follows …..to an average doctor, f@ck it….I don’t need that headache for some Joe Shmo’s Mickey Mouse pain….probably just lying to me to get some addictive evil Oxycodone

Fucking medical establishment and 60-70% of family physicians are relatively incompetent and lack the TRUE knowledge and experience of prescribing controlled substances like Opioid Narcotics

You MUST find a Pain Clinic close to your area who are specialists in prescribing opioids……..have them fax in a referral form to your family doc, they fill out the form and fax back with all your medical records, proof of your accident/surgery/etc……tell them the true story of your situation and you’re in daily serious pain that is dramatically effecting your daily routine, mobility, employment situation, etc.

You have been taking Oxycodone prior and has been a very effective medication for you, and you specifically requested the lowest possible dosage as you’re aware of their tolerance inducing nature, etc

You only take them as needed when pain flairs up and it’s severe pain effecting your quality of life

Request your Oxycodone 10mg XR daily as needed plus a single 5mg IR tablet for “breakthrough” pain which does happen frequently, every pain specialist is aware of this

ALSO……request an NSAID anti-inflammatory (Naproxen) with added GI protection ingredient as it can cause stomach issues, must take with a meal also

This will reassure the pain management specialist you’re not specifically seeking just an addictive narcotic opioid drug and you REALLY have serious pain and are serious about treating your condition, reducing your pain and living a productive active lifestyle …..as you’re entitled to as a human being in a first class nation with modern medicine

Opium usage dating back 3,000 years in ancient mesothelioma as a pain killer and recreational drug…..the name they gave it, directly translates into “plant of joy” lol

Opium poppy
Coca leaves
Cannabis
Ethanol
Psilocybin mushrooms

All dating back THOUSANDS of years …..courtesy of Mother Nature & God

These magical natural medicinal plants specifically binding to our mammalian CNS brains

late 1800’s the Tropane Alkaloid was isolated from the Coca leaf and refined into its water soluble hydrochloride salt….Cocaine HCL.

Opium poppy main alkaloid discovered Morphine, Codeine, theBaine, Papavier……then came Diamorphine (Heroin), Dilaudid (Hydromorphone) and the king of the freaking show Eukadol (Oxycodone)

Courteous of the Father Land……Germany and their brilliant pharmaceutical professionals

Best of luck mate……follow through, you NEED to be seen by a Professional Pain SPECIALIST. Period.

F@CK these shook weak little bitches, you’re standard run of the mill family physician

Cheers :)
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Thank you. Your knowledge is really impressive and helpful 😀

I think the first step is I need to find a “family physician.” My understanding of that is a doctor with a private practice who sees members of your entire family and therefore has a more holistic approach to medicine and well being than, say, a standard doctor at a group practice. Right now, I pretty much just go to a group practice and often don’t even see the same internist, certainly not year to year. So there’s no real relationship or even long term knowledge of me as a patient.

Second step, which I admit I am confused about, but this is perhaps where a good family doctor can assist, is finding a “professional pain specialist.” To date, I just go to generic “pain management” doctors, often from the well known network of doctors you can either google or that even run TV ads (don’t want to name them, but I’m sure people have heard of them). First off, the doctors cycle in and out of these places, so I don’t see the same person every 18 months, so it’s like convincing a new person every time about how dire my situation is (or can be). Obviously this is eventually futile and when I find a doctor who is anti-opioids, I do not want to be viewed as doctor shopping as I go looking around at other pain management facilities.

Anyway, appreciate all the advice. I think I need to focus on step one and find a good family doctor that I can be very open and factual with, without fear of negative consequences. Right now, with my standard internist, I wouldn’t even dare mention that I am in pain and that opioids have helped me through the worst of it, for fear of being labeled a junkie. Even writing that, it pisses me off. I literally have to lie to the person who is supposed to be looking after my overall well-being to ensure a better chance I can be well.
 
Find the right doctor. Every doctor can see what has been prescribed to you. There is nothing wrong going doctor shopping until you find one that will help you. They don’t track that. And besides, it’s a free country. What you are referring to is people would go to one doc, get opiates, then go to another doc and pretend like they hadn’t just got some. But now everything is tracked. No issue in finding a doc who will listen to you and help you. But you need to stand up for yourself and be firm.
 
Orally they are of similar potency, but whereas snorting OC doesn't increase the 'area under the curve' of plasma levels, hydromorphone is about x4 more potent if administered parenterally. I THINK that is why oxycodone was considered 'less abusable'.

Anyone who has snorted 10mg of each will be in no doubt of which is the stronger.

Of course, abusing HM in such a way makes it easy to OD. I always recommend people stick to the prescribed route of prescribed medicines. Altering the ROA can have unexpectedly untoward effects.
 
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