Misc How to Quit Seroquel?

[_DankOpiAmp_]

All neuroleptics are neurotoxic. This is why we are saying what we are saying. No antipsychotic has zero risk of tardive dyskinesia. This condition is caused by brain damage from neuroleptics. It would positively influence your future if you were to inform yourself about alternative medications.

 

[paranoid android]

No antipsychotic has zero risk of tardive dyskinesia.

They all carry the risk of Tardive Dyskinesia but clozapine is a example of one that carries virtually no risk of causing TD or any other anti-psychotic related movement disorders. Quetiapine also has a very low risk of causing it as well as it's not a very strong D2 antagonist at all. Really strong D2 antagonists on the other hand like risperidone, Haldol, Clopixol (Zuclopenthixol) and Pimozide which is a even more potent dopamine antagonist then Haldol do carry a high risk of causing TD.

As for quitting seroquel like any anti-psychotic you have to taper off slowly and preferably under the supervision of a doctor. Quitting anti-psychotics cold turkey can not only cause your original symptoms to come back with a vengeance but it also causes withdrawal effects. Most of the withdrawal symptoms of seroquel at the dose you are on are probably due to it's anti-histamine and D2 antagonism. Older anti-psychotics such as Prochlorperazine (compazine, Stemetil) and good ol Chlorpromazine aka Thorazine aka Largactil are used as anti-nausea drugs. So nausea and vomiting is one symptom of withdrawal from anti-psychotics.

You could try taking a anti-nausea drug such as dimenhydrinate to help the nausea while withdrawing.

 

[5_HT2A]

All neuroleptics are neurotoxic. This is why we are saying what we are saying. No antipsychotic has zero risk of tardive dyskinesia. This condition is caused by brain damage from neuroleptics. It would positively influence your future if you were to inform yourself about alternative medications.

Most of the atypicals are neuroprotective. Look it up on PubMed. Olanzapine and I believe Quetiapine are neuroprotective. TD is caused by rebound supersensitivity among other things due to long term blockade of receptors.

 

[5_HT2A]

They all carry the risk of Tardive Dyskinesia but clozapine is a example of one that carries virtually no risk of causing TD or any other anti-psychotic related movement disorders. Quetiapine also has a very low risk of causing it as well as it's not a very strong D2 antagonist at all. Really strong D2 antagonists on the other hand like risperidone, Haldol, Clopixol (Zuclopenthixol) and Pimozide which is a even more potent dopamine antagonist then Haldol do carry a high risk of causing TD.

As for quitting seroquel like any anti-psychotic you have to taper off slowly and preferably under the supervision of a doctor. Quitting anti-psychotics cold turkey can not only cause your original symptoms to come back with a vengeance but it also causes withdrawal effects. Most of the withdrawal symptoms of seroquel at the dose you are on are probably due to it's anti-histamine and D2 antagonism. Older anti-psychotics such as Prochlorperazine (compazine, Stemetil) and good ol Chlorpromazine aka Thorazine aka Largactil are used as anti-nausea drugs. So nausea and vomiting is one symptom of withdrawal from anti-psychotics.

You could try taking a anti-nausea drug such as dimenhydrinate to help the nausea while withdrawing.

Yeah Clozapine is great, the only atypical that CATIE found to be useful in treatment resistant schizophrenia. Apparently CATIE also found that the atypicals (except Clozapine) show no better efficacy in negative symptoms than typicals, though I see Aripiprazole being good for mania and maybe schizophrenia in some due to partial agonism within mesocortical pathway. Partial agonism is weird, it activates or blocks depending on the presence of endogenous ligands (I believe).