N&PD Moderators: Skorpio | thegreenhand
Clorazepate & picamilon powder are highly soluble in water, but sparingly soluble in ethanol.
How do you preserve those aqueous solutions ? You can't add ethanol since they might precipitate.
Any advice ?
Won't clorazepate degrade in solution by decarboxylation to nordazepam, being a beta-keto-acid?
That seemed to work. Thanks.That said... I don't see why you couldn't create a solution of clorazepate from diluted alcohol. 20% ethanol in water should still be able to dissolve it at common dosages (diazepam solutions are typically around 5 mg per mL, which would be equivalent to about 10 mg of clorazepate per mL).