That part makes sense, Kief, but then that would apply only up until the drug is absorbed. But many half lives need to pass before a drug is eliminated. So, for bupe, the half life is something like 36 hours sublingual and 8 hours IV. Say you have two people, one who shoots 2mg and another who puts 2mg under his tongue. A day or two later, when presumably all the drug is absorbed, how does the shooter’s liver know to keep the pace of halving every 8 hours and the others guy‘s liver know to keep a pace of every 36?
or is 8 hours the real half life? Once the drug is fully absorbed by whatever roa is this the true pace of elimination?