Nitrous Tolerance
I've been inhaling nitrous for approximately 17 years. The most I've ever inhaled at once was 50 whip-it cartridges in one 3 foot diameter balloon. The experience of fading reality and absence of mind, that usually lasts a few seconds, was - at the time of the 50 cartridges experience - about 3-5 minutes. Other than that, I can say that at this point nitrous has very little effect on me. If I buy it in whip-its the least I need is 100 and if I get in a tank I'll finish it within a few days with little to no effect. I no longer have any audio distortions and no visuals - not even behind the eye visuals. The only thing that remains, after 17 years of pretty much daily use, is a slightly warm feeling that will last as long as the nitrous does but immediately goes away when the supply is out. The way I use it is to breath it in with my mouth and exhale it through my nose, taking breaths of oxygen every 2-3 minutes. If I'm using whip-its, I use the standard cafe cracker (the largest one will typically hold about 5 cartridges,) and inhale it very slowly and start to "breathe" it in - after a few minutes, inhaling and exhaling. *This manner of use will limit EXTREME highs, but it will give highs that last considerably longer. After about the first 10 or 11 years, I started to feel the effects of nitrous tolerance. At 12 years of using it, I was diagnosed with Pernicious Anemia - which my Neurologist told me would be fatal if I continued to do Nitrous without a prescription of daily IM injectable Vitamin B (Cyanobalamin) which I had to use for about 5 years - both when I was doing nitrous, which at that point was more like weekly, but also had to inject daily at other times when I wasn't using. It was only at the beginning of this year (2017) that I was finally in remission from Pernicious Anemia. (In the interim I had one episode of extremely low vitamin B that landed me in the hospital for over a week and the experience was crazy. I couldn't remember anything - even my name and there were points when I would just scream even though I wasn't trying to.) I NEVER wanted to experience that again, so I limited my use after that. I've experienced a lot of drugs: MDMA, LSD, psilocybin, amphetamines - both crystal & prescription, cocaine, oxy, xanax, alcohol and nicotine and I never felt any kind of need or addiction to any of them. (I suppose xanax might be an exception if you count going several years looking for a way to detox from it and ultimately having to go inpatient medically to be hooked up to a feeding tube and unconscious for 3 days - because of an unrelated event - but one that finally helped me to detox permanently from it. But other than the need to prevent seizure like symptoms from setting in, there was never any 'feeling' I got from xanax that made me actually want to use it regularly.) When I first started using nitrous, it was in combination with other psychedelics and using it on its own just gave me a headache and never any kind of hallucinatory experience. After undergrad, I started 150mg/daily of Effexor (the chemical basis of which is the same as MDMA,) and it was at that point that nitrous started to have a desirable effect. And it was at that point that I started using it more regularly. I've had phases where I've gone 6 months or so without using it at all but the tolerance doesn't seem to change.