SpunkySkunk347
Bluelighter
- Joined
- Jan 15, 2006
- Messages
- 1,719
Felt like this needed to be in the original post:
A main metabolite of acetaminophen is toxic to liver tissue on contact. Any amount of acetaminophen damages the liver.
The liver does have enough enzymes for a few grams of acetaminophen to metabolize it and its toxic metabolite, but after about 3-5 grams this enzyme becomes increasingly occupied in a sense, and the liver 'runs out' of it and has to begin making more.
Anything above 4 grams is causing a more substantial level of damage to the liver.
4 grams a day will kill the liver eventually.
6 grams every day will kill the liver a little more rapidly (a year and a half or so).
8 grams a day will kill the liver in less than a year, even just a few months, and can be a lethal single dose
8 grams at once can be lethal, and is approximately where the bell curve for lethal dose becomes apparent
10 grams a day will kill the liver in just a few months, and even from a single use (now substantially on the bell curve for Lethal Dose)
12 grams is well up on the bell curve for Lethal Dose
14 grams is on the other side of the bell curve for Lethal Dose (14 grams will kill most people who take it)
20 grams at once is almost certain death
These numbers are pretty much what most people have stated the dangerous/lethal doses to be over the years, and staying below them has kept many of us alive.
You SHOULD be doing a Cold Water Extraction if you're going to take large amounts of opioids paired with acetaminophen.
Remember, any large single dose of acetaminophen causes long term damage to the liver (4 grams or more, like someone with a tolerance who takes nine 5 mg hydrocodone 500mg acetaminophen pills to get high, which is 4500mg of acetaminophen).
It takes years, even decades, for the liver to recover from the damage that large doses of acetaminophen do to it, If The Liver Can Even Recover At All
Remember, 4 grams a day is different from 4 grams at once.
Taking 4 grams at once every day will kill the liver a LOT sooner than 4 grams taken over the course of each day.
The first number that turns up on google is a lie (the top link, you know, the paid for one); it says something like 300, but I distinctly remember a number around 40,000 annually when I first heavily researched the topic in the mid 2000s
So either A) people started reading about the dangers of acetaminophen online, all started doing cold water extractions, and quit dying from it.
Or B) there is a massive cover up ongoing that might have something to do with liver availability and black market donor lists for non-donors having their organs donated anyways.
The LD50 for humans is somewhere around 12-14 grams; 20 grams is pretty much guaranteed death... 12 grams is certainly well on the bell curve, and 20 grams is certainly past the top of it and on the other side of the bell curve.
That's one bottle. One effing bottle. One bottle of thirty to sixty 5/500s taken over a friday night and a saturday morning, or a bottle or two of cough syrup.
Then consider that there's enough opiates and opioids imported into the country legitimately for every man, woman, and child to be able to be on a standard dose of opioid/opiate pain medication all hours of the day. So statistically, we're either all opiate/opioid users or 1 out of 8 people is taking 8 times the amount they're supposed to.
And there are new users every day.
One statistic doesn't make sense: there are ~40,000 deaths from liver failure per year, yet only ~8,000 transplants performed. Why? Those are relatively small numbers, and with 2.8 million deaths per year, there should be no shortage. This suggests that transplant numbers are covered up due to the 'non-donor' phenomenon, where people who don't list donor on their license have their organs donated anyways, leading to fake numbers for anything connected with the issue.
According to numerous links on google, "Acetaminophen overdose is the leading cause of acute liver failure."
Given the sheer metric tonnage of opiates and opioids consumed annually I'd place the actual number of acetaminophen overdoses as somewhere in the hundreds of thousands. Of these, probably 60% are treated with antidote relatively early, and roughly 35% include things like chronic overdosing and require transplant, which has a mortality rate of something like more than 10% - giving us an estimate for deaths with a failed transplant at 3,500-10,000 already. Add in a few hundred who never made it to the hospital, another few hundred who although they made it to the hospital their condition went untreated (no antidote and no liver waiting list), and then tens of thousands (give or take) who die before a new liver can arrive and be transplanted.
Even with the numbers that DO exist, 40,000 deaths from acute liver failure a year and acetaminophen being the leading cause of it suggest a number far greater than just a few hundred.
Unbelievable the amount of cover-ups.. where do they even stop?
A main metabolite of acetaminophen is toxic to liver tissue on contact. Any amount of acetaminophen damages the liver.
The liver does have enough enzymes for a few grams of acetaminophen to metabolize it and its toxic metabolite, but after about 3-5 grams this enzyme becomes increasingly occupied in a sense, and the liver 'runs out' of it and has to begin making more.
Anything above 4 grams is causing a more substantial level of damage to the liver.
4 grams a day will kill the liver eventually.
6 grams every day will kill the liver a little more rapidly (a year and a half or so).
8 grams a day will kill the liver in less than a year, even just a few months, and can be a lethal single dose
8 grams at once can be lethal, and is approximately where the bell curve for lethal dose becomes apparent
10 grams a day will kill the liver in just a few months, and even from a single use (now substantially on the bell curve for Lethal Dose)
12 grams is well up on the bell curve for Lethal Dose
14 grams is on the other side of the bell curve for Lethal Dose (14 grams will kill most people who take it)
20 grams at once is almost certain death
These numbers are pretty much what most people have stated the dangerous/lethal doses to be over the years, and staying below them has kept many of us alive.
You SHOULD be doing a Cold Water Extraction if you're going to take large amounts of opioids paired with acetaminophen.
Remember, any large single dose of acetaminophen causes long term damage to the liver (4 grams or more, like someone with a tolerance who takes nine 5 mg hydrocodone 500mg acetaminophen pills to get high, which is 4500mg of acetaminophen).
It takes years, even decades, for the liver to recover from the damage that large doses of acetaminophen do to it, If The Liver Can Even Recover At All
Remember, 4 grams a day is different from 4 grams at once.
Taking 4 grams at once every day will kill the liver a LOT sooner than 4 grams taken over the course of each day.
The first number that turns up on google is a lie (the top link, you know, the paid for one); it says something like 300, but I distinctly remember a number around 40,000 annually when I first heavily researched the topic in the mid 2000s
So either A) people started reading about the dangers of acetaminophen online, all started doing cold water extractions, and quit dying from it.
Or B) there is a massive cover up ongoing that might have something to do with liver availability and black market donor lists for non-donors having their organs donated anyways.
The LD50 for humans is somewhere around 12-14 grams; 20 grams is pretty much guaranteed death... 12 grams is certainly well on the bell curve, and 20 grams is certainly past the top of it and on the other side of the bell curve.
That's one bottle. One effing bottle. One bottle of thirty to sixty 5/500s taken over a friday night and a saturday morning, or a bottle or two of cough syrup.
Then consider that there's enough opiates and opioids imported into the country legitimately for every man, woman, and child to be able to be on a standard dose of opioid/opiate pain medication all hours of the day. So statistically, we're either all opiate/opioid users or 1 out of 8 people is taking 8 times the amount they're supposed to.
And there are new users every day.
One statistic doesn't make sense: there are ~40,000 deaths from liver failure per year, yet only ~8,000 transplants performed. Why? Those are relatively small numbers, and with 2.8 million deaths per year, there should be no shortage. This suggests that transplant numbers are covered up due to the 'non-donor' phenomenon, where people who don't list donor on their license have their organs donated anyways, leading to fake numbers for anything connected with the issue.
According to numerous links on google, "Acetaminophen overdose is the leading cause of acute liver failure."
Given the sheer metric tonnage of opiates and opioids consumed annually I'd place the actual number of acetaminophen overdoses as somewhere in the hundreds of thousands. Of these, probably 60% are treated with antidote relatively early, and roughly 35% include things like chronic overdosing and require transplant, which has a mortality rate of something like more than 10% - giving us an estimate for deaths with a failed transplant at 3,500-10,000 already. Add in a few hundred who never made it to the hospital, another few hundred who although they made it to the hospital their condition went untreated (no antidote and no liver waiting list), and then tens of thousands (give or take) who die before a new liver can arrive and be transplanted.
Even with the numbers that DO exist, 40,000 deaths from acute liver failure a year and acetaminophen being the leading cause of it suggest a number far greater than just a few hundred.
Unbelievable the amount of cover-ups.. where do they even stop?
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