How does replacing the chlorine moiety on ketamine with non-halogens effect it?

[:DNA]

Hello, NPD!

I have recently become interested in better understanding the neuropharmacology and SAR of ketamine -- specifically the significance of the chlorine group for its neuropharmacological and neurophysiological effects -- but am having trouble finding papers/studies that explore this. Have the neurotrophic and/or toxicity aspects of replacing it with a methyl, -OH or nitrogen group (or even removing it entirely) been studied? Could modifying this group fundamentally alter the mechanism underlying its purported currently-being-explored antidepressant effect somehow, and if so, would anyone be so kind to explain this in more detail for me?

Thanks in advance

 

[:DNA]

*affect

 

[Dresden]

You mean like this?

I would imagine it's pretty damn good.

 

[.:Holy::Toast:.]

Based on trip reports of 2-MeO-ketamine it seems to weaken the euphoria and increase the duration