Phil.McKeer
Bluelighter
- Joined
- Jul 20, 2015
- Messages
- 905
I can't believe I never really thought about this before, but...we all know that the BA of sublingual buprenorphine (suboxone, subutex, zubsolv, etc) is around ~30%, and subutex taken intranasally increases BA slightly to around ~45% (right?).
So my question is, when y'all taper down and are taking ~0.5mg, are you literally taking 1/16th of your sub (literally 0.5mg BEFORE absorption/BA) or are you taking 1.5mg's and calculating that you've absorbed 0.5mg?
I've been taking 0.5mg every day since I tapered down (I tried to jump off but the depression - which existed before abusing H - was too much when compounded with PAWS and I started taking literally 1/16th of a subutex intranasally everyday, which has worked very well). So that means I've really been taking ~0.2mg after BA is factored in.
How do you calculate how much you've taken? By weight, or by bioavailability after absorption?
So my question is, when y'all taper down and are taking ~0.5mg, are you literally taking 1/16th of your sub (literally 0.5mg BEFORE absorption/BA) or are you taking 1.5mg's and calculating that you've absorbed 0.5mg?
I've been taking 0.5mg every day since I tapered down (I tried to jump off but the depression - which existed before abusing H - was too much when compounded with PAWS and I started taking literally 1/16th of a subutex intranasally everyday, which has worked very well). So that means I've really been taking ~0.2mg after BA is factored in.
How do you calculate how much you've taken? By weight, or by bioavailability after absorption?