Herkinorin

[kleinerkiffer]

While skimming through varius papers about the pharmacology of Salvia divinorum I found this:

https://books.google.de/books?id=aw...DAA#v=onepage&q=salvinorin A benzoate&f=false
"Salvinorin A was found to be a potent and selective agonist for the kappa opioid receptor. Modification of the C-2 acetate group of salvinorin A by a benzoate results in a compound with affinity and selectifity for the mu opioid receptor termed herkinorin. Herkinorin represents the first non-nitrogenous mu opioid receptor agonist discovered.
Herkinorin was shown to activate the mu opioid receptor without recruitment of ß-arrestin 2 and also without causing internalization of the receptor from cell surface in vitro. Using a rodent model of nociception, herkinorin was shown to be active in vivo. More importantly, because of the unique way herkinorin activates the mu opioid receptor, it does not produce tolerance over a 5 day period and it remains active in animals that have become tolerant to the antinociceptive effects of morphine."



Here's an old thread about it http://www.bluelight.org/vb/threads...-extremely-potent-opioid-w-unusual-properties

But sadly no one tried it afaik and it looks like there hasn't been any more research ?

 

[fatchains]

I can order it but I cant get more than 10-20mg (from a scientific suppier). Its not cheap so I wanted to know the dose.

 

[fatchains]

BTW- I think this might interest you- it how i found out about it
Synthesis of Salvinorin A Analogues as Opioid Receptor Probes


Id like that article but in between postdocs- no access

 

[Nagelfar]

Id like that article but in between postdocs- no access

Personally, I just read a newspaper article about PZM21 which looked quite promising.