HEPATOXICITY and LIVER DAMAGE

[risadinha]

HEPATOXICITY AND LIVER DAMAGE

ok guys so couple weeks ago I went rolling really hard, for 4 days in a roll, the last day I even took 4 pills at once.
I know it was a bad idea and because of that I got HEPATOXICITY, eyes really yellow, itching alot and even my piss was really Yellow. this was all do to the high quantity of chemicals that I sent to my liver. its been 3 weeks and each week I have been getting better, the yellowness started to fade away, piss back to normal color and so one.

Questions:
Has any one ever gone through this??? how long did it take to get back normal, and how long did they wait until they rolled again???
any other info about a related experience is very appreciated!!

 

[Epsilon Alpha]

Yeah, you should probably see a doctor. MDMA is well known to cause liver damage. The liver has some amazing regenerative abilities, however you should not test it. Not really ADD, but I'll leave this open for a day or two to see what the other mods want to do. It would be wise to avoid drinking alcoholic beverages until you're cleared by a doctor. If you absolutely need an excuse to ask say your friend made a dish with wild mushrooms or something like that and you want to be checked out.

Long story short: don't roll again if you've experienced signs of hepatic injury that you attribute to the roll. See a doctor also, as liver damage is a VERY difficult topic to subjectively assess.

Edit: here's a decent article on the topic http://www.ncbi.nlm.nih.gov/m/pubmed/20420570/

 

[sekio]

MDMA is well known to cause liver damage.

I'm sorry, EA, I have to call you on this - I haven't ever actually heard of MDMA being a direct cause of liver toxicity before now! I was positive that in most cases of suspected "MDMA toxicity" the real culprits were mismanaged hyperthermia or a combination of physical exhaustions simply driven by the stimulant nature of the compound, not by any direct toxic effect it or any of its metabolites have... At least, I got the impression that in most cases of death from "MDMA tox" the true cause was way more than just the MDMA!

Either way, after partying for (probably more than) four days straight, some combination of dehydration, stress, poor nutrition, poor hydration, too many drugs, bad food, impurities, or whatever just made your liver strain. It's not neccesarily indicative of the MDMA being the problem....

 

[Epsilon Alpha]

I'm sorry, EA, I have to call you on this - I haven't ever actually heard of MDMA being a direct cause of liver toxicity before now! I was positive that in most cases of suspected "MDMA toxicity" the real culprits were mismanaged hyperthermia or a combination of physical exhaustions simply driven by the stimulant nature of the compound, not by any direct toxic effect it or any of its metabolites have... At least, I got the impression that in most cases of death from "MDMA tox" the true cause was way more than just the MDMA!

Either way, after partying for (probably more than) four days straight, some combination of dehydration, stress, poor nutrition, poor hydration, too many drugs, bad food, impurities, or whatever just made your liver strain. It's not neccesarily indicative of the MDMA being the problem....

Its pretty well known actually, the current theories are it 1) forms toxic metabolites and/or 2) its metabolites trigger a TNF-alpha mediated immune response. Heat doesn't help, but its hepatotoxic on its own right. Makes a lot of sense looking at the hepatotoxicity of sassafras oil.

Many of the direct deaths from MDMA are due to liver failure or weird electrolyte unbalancing effects (yes that's even taking into account drinking too much water).
http://www.jgld.ro/2011/2/20.pdf
http://www.ncbi.nlm.nih.gov/pubmed/21871945
http://www.ncbi.nlm.nih.gov/pubmed/20420577
http://www.ncbi.nlm.nih.gov/pubmed/21204248
http://www.ncbi.nlm.nih.gov/pubmed/20599925
http://www.ncbi.nlm.nih.gov/pubmed/22151050
http://www.ncbi.nlm.nih.gov/pubmed/21864684

 

[Foreigner]

I don't think it's black or white, and is probably dependent on a person's CYP450 polymorphisms. Some people cannot process drugs as effectively as others, which is why in pharmacy we have side effect profiles ranging from mild/common to severe/rare. For all we know, the fatal cases are the result of people suffering from rare side effects and not being able to process the drug in a safe manner, or they are slow metabolizers so higher doses linger in the system for longer, causing hepatic burden. Admittedly, it's hard to isolate such factors given that recreational use tends to coincide with over-exertion of the body, poor nutrition/hydration, etc.

 

[gemini088]

Sounds like you may have a form of hepatitis? Get checked and start treatment if you must.