Slid said:thats what I thought (about the natural stuff). Do I need to be careful with liver damage with any aminos? -- ill probably be giving her some kava along with ibuprofen, thats why i ask.
Substituting one amphetamine with another prevents relapse? Wow, who would have though so.scream said:Theres a study (maybe not her cup of tea..but) which shows Dexamphetamine substitution very good at preventing relapse.
This will be a very interesting study to read. Can't wait until you post it.Psychubus said:please, no 5-htp. i know a lot of people on this site like it, but your body CAN develop a dependency to it
Psychubus said:please, no 5-htp. i know a lot of people on this site like it, but your body CAN develop a dependency to it, .
I'm sure she means that your brain adapts to having a surplus of serotonin.rocklobster said:This will be a very interesting study to read. Can't wait until you post it.
5-HTP supplementation does not create a surplus of serotonin. Your body only converts what it needs, and the rest is wasted. All of the 5-HTP does not magically turn into serotonin just because you've ingested it.BollWeevil said:I'm sure she means that your brain adapts to having a surplus of serotonin.
This has been discussed a few times; here's a few just from a quick search:rocklobster said:5-HTP supplementation does not create a surplus of serotonin. Your body only converts what it needs, and the rest is wasted. All of the 5-HTP does not magically turn into serotonin just because you've ingested it.
and the amounts of 5-HTP used are insanely large. There is nothing to show that all 5-HTP in small-to-moderate doses downregulates serotonin receptors or production, and certainly nothing that shows that your body develops a dependency on it, as psychobitch posted.L-5-Hydroxytryptophan (5-HTP) is a clinically useful antimyoclonic drug that is thought to act at serotonin (5-HT) receptors after decarboxylation to 5-HT. However, the chronic effects of 5-HTP on central 5-HT receptors and the activity of 5-HTP at 5-HT receptor subtypes have not been previously reported. In rats treated 28 but not 7 consecutive days with high doses of 5-HTP (50-200 mg/kg), cortical 5-HT2 ( -20% ) and 5-HT1 ( -11% ) sites were downregulated without altered receptor affinity, but only the changes in 5-HT2 sites were significant. In naive frontal cortex in vitro, however, 5-HTP and 5-HT were more active at 5-HT1 sites, and 5-HTP was inactive at 5-HT2 sites. The differential effects of high-dose 5-HTP on 5-HT receptors suggest that 5-HT2 receptor downregulation may be relevant either to the antimyoclonic effect of chronic 5-HTP therapy in posthypoxic myoclonus or to development of tolerance.