Hi,
A friend of my partner is a binge drinker. She has tried and failed to escape her dependence and addiction but time is running out and so are options. I know from personal experience as well as data provided by clients that only this drug (without being able to test barbiturates) is left. It really did totally stop the cravings. Now, I'm sure you have read details of pyeyzolam & QH-II-66 but I have none to offer and am not qualified or experienced enough to prescribe medications. I have an idea and I would like some help and feedback. I promise you now that anyone who can help me today will always know that I owe them a favour and my word is my bond. So....
-Clomethiazole is now only used in an in-patient setting because mixed with other CNS depressants, it is awfully toxic.
-If a single dose is provided once a day it will provide 6-8 hours relief from the cravings (and physical harm).
-I cannot find the affinity data on clomethiazole. I really need to know and to be able to explain to this persons doctor WHY I am suggesting the idea.
-I know that the oxazole homologue was made but while the Eunoia Disc has the patent (US 3401172), it has no clinical research data. Does anyone have data on that?
-I am going to suggest supervised consumption with a concomitant dose of an alcohol dehydrogenase inhibitor.
-There are several possible 'add on' medications such as naltrexone, nalmefene or other agent to blunt euphoria but then 2 drugs is already a risk.
-We now all know that all of the good and all of the bad (apart from feeling hungry) is mediated by the α5β1 sub-unit of the GABAa receptors and it is the RATIO of modulation between the 4 diazepam-sensitive sub-units that is responsible for the subjective effects. Should I tell the doctor this? If so, how? I do not wish to talk down to them but neither should or will I talk up to them.
-Are there viable alternatives available in the BNF? If so what? If what, why?
-Apart from 'Strong Vitamin B complex', is there anything else to minimize damage?
-If people believe I am wrong, will you please tell me? Tell me why because I am ALWAYS happy to be corrected but gainsaying is beneath me (but it has never happened here so it's me overthinking things).
-Has anyone else been through such an experience? What data and advice can you give?
-It took me 6 months for the cravings to subside and then I was depressed for a good 2 years. No SSRI helped and at the time the doctor was unwilling to give me chloripramine.
-Is there a specific drug or class of drugs that help with post-acute withdrawal syndrome?
-Is there anything else you have experienced, know or know of I should look into?
-Please provide references if you can find them? If you have a .PDF of a useful paper, can you upload or rewrite in your own words the important bit? My periodical having is costing me 25% of my income as it is so spending ?300 and then discovering only one paper, the ?18 one is of value.
-Have I missed anything.
I would just like to thank you all in advance. A special thanks to all of those people who have already helped me, I love the people here. This really is the last chance. They will be dead in 4-6 months if we cannot find an answer. If it all goes well I can submit a paper to The Lancet (and obviously Lifeline, Michael Linnell, Russell Newcombe (Dr. Nuke), Nick and DDN) so you might want to think about an alias. I use an anagram of my name. If you look at the credits in a lot of Lifeline (Now Linnell Communications) booklets, yes, that one is me - you WILL know the one. Of course, a lot of you DO know who I am, but no full names on the boards, please, employers do search the web and this would not be a good place to show up.
A friend of my partner is a binge drinker. She has tried and failed to escape her dependence and addiction but time is running out and so are options. I know from personal experience as well as data provided by clients that only this drug (without being able to test barbiturates) is left. It really did totally stop the cravings. Now, I'm sure you have read details of pyeyzolam & QH-II-66 but I have none to offer and am not qualified or experienced enough to prescribe medications. I have an idea and I would like some help and feedback. I promise you now that anyone who can help me today will always know that I owe them a favour and my word is my bond. So....
-Clomethiazole is now only used in an in-patient setting because mixed with other CNS depressants, it is awfully toxic.
-If a single dose is provided once a day it will provide 6-8 hours relief from the cravings (and physical harm).
-I cannot find the affinity data on clomethiazole. I really need to know and to be able to explain to this persons doctor WHY I am suggesting the idea.
-I know that the oxazole homologue was made but while the Eunoia Disc has the patent (US 3401172), it has no clinical research data. Does anyone have data on that?
-I am going to suggest supervised consumption with a concomitant dose of an alcohol dehydrogenase inhibitor.
-There are several possible 'add on' medications such as naltrexone, nalmefene or other agent to blunt euphoria but then 2 drugs is already a risk.
-We now all know that all of the good and all of the bad (apart from feeling hungry) is mediated by the α5β1 sub-unit of the GABAa receptors and it is the RATIO of modulation between the 4 diazepam-sensitive sub-units that is responsible for the subjective effects. Should I tell the doctor this? If so, how? I do not wish to talk down to them but neither should or will I talk up to them.
-Are there viable alternatives available in the BNF? If so what? If what, why?
-Apart from 'Strong Vitamin B complex', is there anything else to minimize damage?
-If people believe I am wrong, will you please tell me? Tell me why because I am ALWAYS happy to be corrected but gainsaying is beneath me (but it has never happened here so it's me overthinking things).
-Has anyone else been through such an experience? What data and advice can you give?
-It took me 6 months for the cravings to subside and then I was depressed for a good 2 years. No SSRI helped and at the time the doctor was unwilling to give me chloripramine.
-Is there a specific drug or class of drugs that help with post-acute withdrawal syndrome?
-Is there anything else you have experienced, know or know of I should look into?
-Please provide references if you can find them? If you have a .PDF of a useful paper, can you upload or rewrite in your own words the important bit? My periodical having is costing me 25% of my income as it is so spending ?300 and then discovering only one paper, the ?18 one is of value.
-Have I missed anything.
I would just like to thank you all in advance. A special thanks to all of those people who have already helped me, I love the people here. This really is the last chance. They will be dead in 4-6 months if we cannot find an answer. If it all goes well I can submit a paper to The Lancet (and obviously Lifeline, Michael Linnell, Russell Newcombe (Dr. Nuke), Nick and DDN) so you might want to think about an alias. I use an anagram of my name. If you look at the credits in a lot of Lifeline (Now Linnell Communications) booklets, yes, that one is me - you WILL know the one. Of course, a lot of you DO know who I am, but no full names on the boards, please, employers do search the web and this would not be a good place to show up.