Misc Half life question?

[Slow_Mobius]

Dobalina haven't you said you're taking the lamictal to help with seizures? What kind of epilepsy do you have? It sounds like you might be putting yourself at serious risk

 

[Mr Dobalina]

I don't have epilepsy, the neurologist doesn't know why I had the two seizures. I don't want to take the Lamictal because it blocks most drugs. Once the Lamictal is out of my system I'm going to take a Benzo before I take drugs to prevent seizures.

 

[Slow_Mobius]

Gotcha. Were the seizures associated with any drug use?

 

[Tranced]

I don't have epilepsy, the neurologist doesn't know why I had the two seizures. I don't want to take the Lamictal because it blocks most drugs. Once the Lamictal is out of my system I'm going to take a Benzo before I take drugs to prevent seizures.

Given that you use benzos, are you sure it wasn't benzo induced? I had a similar situation back in 2008 when I had three alprazolam induced seizures. It wasn't until after the second that I had any idea that alprazolam was causing them, let alone the neurologist (they didn't know I was taking it). I didn't realise how easily benzos could induce seizures, or that using daily for the best part of a week at a time was enough to do so.

 

[Mr Dobalina]

Gotcha. Were the seizures associated with any drug use?

My first seizure was with Tiagabine. I read it's used off label for anxiety so I got some & didn't realize until after that as well as being an anti convulsant it can also cause seizures which I find wierd. My second seizure wasn't drug induced.
I'm guessing the Tiagabine triggered something in my brain and that's why I had another seizure.

 

[Mr Dobalina]

Given that you use benzos, are you sure it wasn't benzo induced? I had a similar situation back in 2008 when I had three alprazolam induced seizures. It wasn't until after the second that I had any idea that alprazolam was causing them, let alone the neurologist (they didn't know I was taking it). I didn't realise how easily benzos could induce seizures, or that using daily for the best part of a week at a time was enough to do so.

Nope...I wasn't using Benzos at the time.
Are you on medication now or because the seizures were Benzo induced you don't have to?

 

[Tranced]

My first seizure was with Tiagabine. I read it's used off label for anxiety so I got some & didn't realize until after that as well as being an anti convulsant it can also cause seizures which I find wierd. My second seizure wasn't drug induced.
I'm guessing the Tiagabine triggered something in my brain and that's why I had another seizure.

Anti-convulsants directly affect the seizure threshold, so it does make sense.

How long after the first seizure did you have the second? Had you been taking anything within, just say, a week of it?

Just interested because like I say, the fact that I'd had a benzo induced seizure completely eluded me. I'm not trying to say it was benzos with you by the way, just intrigued as to whether there is a connection with something.

 

[Scrofula]

I poked around since you're X-posting sot of in the gabapentin thread, and it looks like tiagabine (GABA reuptake inhibitor) toxicity can involve seizures. Found a meta-study that excluded polydrug cases and still reports seizures, the lowest dose being 96mg, but in an epileptic patient: http://www.tandfonline.com/doi/abs/10.1080/15563650500357529?journalCode=ictx20


One case report of a seizure associated with pregabalin but it was in a patient with genetic issues causing severe epilepsy.
No reports so far on gabapentin toxicity causing seizures (and I think the weird kinetics mean you can only have so much circulating gabapentin, a level I'm pretty sure I've eaten by now).

Nary a word on seizures occurring with benzo overdose, which is actually weird, since there's so many of them, and people really like to eat them.

So @Tranced, there's just no reason three Xanax should cause seizures unless you're already epileptic. People out there have eaten a hundred I'm sure and not had seizures.

 

[Mr Dobalina]

Anti-convulsants directly affect the seizure threshold, so it does make sense.

How long after the first seizure did you have the second? Had you been taking anything within, just say, a week of it?

Just interested because like I say, the fact that I'd had a benzo induced seizure completely eluded me. I'm not trying to say it was benzos with you by the way, just intrigued as to whether there is a connection with something.

So an anti convulsant can cause a seizure even though they are supposed to prevent them? How does that make sense?

I had my second seizure about five months later & I was pretty clean during that time, I only smoked about a gram of meth (not all at once)

 

[Mr Dobalina]

I poked around since you're X-posting sot of in the gabapentin thread, and it looks like tiagabine (GABA reuptake inhibitor) toxicity can involve seizures. Found a meta-study that excluded polydrug cases and still reports seizures, the lowest dose being 96mg, but in an epileptic patient: http://www.tandfonline.com/doi/abs/10.1080/15563650500357529?journalCode=ictx20


One case report of a seizure associated with pregabalin but it was in a patient with genetic issues causing severe epilepsy.
No reports so far on gabapentin toxicity causing seizures (and I think the weird kinetics mean you can only have so much circulating gabapentin, a level I'm pretty sure I've eaten by now).

Nary a word on seizures occurring with benzo overdose, which is actually weird, since there's so many of them, and people really like to eat them.

So @Tranced, there's just no reason three Xanax should cause seizures unless you're already epileptic. People out there have eaten a hundred I'm sure and not had seizures.

Yeah it would have been Tiagabine toxicity because I was impatient & didn't think they were working so I kept taking more.

How come you found no reports on Gabapentin seizures?
I found plenty.

 

[Scrofula]

If you're finding gabapentin-induced seizure reports, it's some kind of scam.

Edit: are you seeing stuff on myoclonus? Those are "jerky" movements, but not actual seizures.

 

[Slow_Mobius]

So an anti convulsant can cause a seizure even though they are supposed to prevent them? How does that make sense?

I had my second seizure about five months later & I was pretty clean during that time, I only smoked about a gram of meth (not all at once)

It sounds like you're naturally seizure prone. One of the risk factors for having seizures is having already had seizures. You should really avoid stimulants, and it would probably be a good idea to take the seizure medication.

Did you explain the meth to the neurologist?

 

[Mr Dobalina]

If you're finding gabapentin-induced seizure reports, it's some kind of scam.

Edit: are you seeing stuff on myoclonus? Those are "jerky" movements, but not actual seizures.

It says on the epilepsysociety website it may make Myoclonic and abscence seizures worse.

www.epilepsysociety.org.uk/gabapentin

 

[Mr Dobalina]

It sounds like you're naturally seizure prone. One of the risk factors for having seizures is having already had seizures. You should really avoid stimulants, and it would probably be a good idea to take the seizure medication.

Did you explain the meth to the neurologist?

No I didnt explain the meth to the neurologist.
I dont wanna take the medication because I wanna take drugs. I can prevent seizures by taking Benzos or Tiagabine.

 

[Tranced]

I poked around since you're X-posting sot of in the gabapentin thread, and it looks like tiagabine (GABA reuptake inhibitor) toxicity can involve seizures. Found a meta-study that excluded polydrug cases and still reports seizures, the lowest dose being 96mg, but in an epileptic patient: http://www.tandfonline.com/doi/abs/10.1080/15563650500357529?journalCode=ictx20


One case report of a seizure associated with pregabalin but it was in a patient with genetic issues causing severe epilepsy.
No reports so far on gabapentin toxicity causing seizures (and I think the weird kinetics mean you can only have so much circulating gabapentin, a level I'm pretty sure I've eaten by now).

Nary a word on seizures occurring with benzo overdose, which is actually weird, since there's so many of them, and people really like to eat them.

So @Tranced, there's just no reason three Xanax should cause seizures unless you're already epileptic. People out there have eaten a hundred I'm sure and not had seizures.

Oh it wasn't from an overdose, it was during withdrawal.

So an anti convulsant can cause a seizure even though they are supposed to prevent them? How does that make sense?

I had my second seizure about five months later & I was pretty clean during that time, I only smoked about a gram of meth (not all at once)

Because you're messing with your seizure threshold, which would ordinarily (in non epeleptic people etc) remain stable. I'm referring mainly to the withdrawal phase of using a drug, but I could imagine that it would happen before then too.

 

[Blind Melon]

Gauging the time needed to eliminate substances from your system can be a real tricky bitch. Whether it's for a drug test, or just being aware of the "stacking" effect that occurs when a body begins daily dosing the longer acting drugs. (Methadone and Valium are known for their epic half-lives).

I regularly take the same dose of benzodiazepines but due to various factors I've yet to identify I will sometimes test negative for benzos 2 days after a single 2mg dose of Xanax, and I will sometimes test positive up to 5 days after a single 2mg dose of Xanax. And yet I can regularly smoke cannabis for a month or more, quit, and test clean a week later. Who knows? I think diet, hydration and sleep are likely the main factors.

 

[Scrofula]

It says on the epilepsysociety website it may make Myoclonic and abscence seizures worse.

www.epilepsysociety.org.uk/gabapentin

Yeah, keep in mind that epilepsy is a big broad umbrella of disorders, with all kinds of sources, and so psychoactive meds will work differently and unpredictably (to a non-specialist).

Have we figured out if you're epileptic or not OP? (Or I guess seizure-prone?) Cause if you are, you need to be seeing a specialist on the regular. If it were me, I'd avoid coffee even (disclosure: had full seizure during booze withdraw).

 

[Mr Dobalina]

Yeah, keep in mind that epilepsy is a big broad umbrella of disorders, with all kinds of sources, and so psychoactive meds will work differently and unpredictably (to a non-specialist).

Have we figured out if you're epileptic or not OP? (Or I guess seizure-prone?) Cause if you are, you need to be seeing a specialist on the regular. If it were me, I'd avoid coffee even (disclosure: had full seizure during booze withdraw).

Oh ok.
No the neurologist didn't say I was epileptic, he has no idea why I had my second seizure (my first was due to an overdose of Tiagabine)

Its just shit because Lamictal blocks the effects of most drugs and I like to take something every now and then..ive calmed down alot since I was younger. Im just going to quit the Lamictal and take Klonopin before I take drugs since that is what they gave me in Hospital when I had my first seizure, so it must be pretty good at preventing seizures.

 

[Scrofula]

I think someone mentioned the "kindling" thing, where each seizure you have increases the odds of another. Your second one was like an aftershock.

(Honestly I felt grrrrreat after mine. Seriously. I'd ask for another if it weren't for that "stopped breathing" thing.)

Any benzo will help prevent seizures, not just Klonopin, but be careful you don't pick up a habit of those, cause they're nasty to get off.

 

[Mr Dobalina]

I think someone mentioned the "kindling" thing, where each seizure you have increases the odds of another. Your second one was like an aftershock.

(Honestly I felt grrrrreat after mine. Seriously. I'd ask for another if it weren't for that "stopped breathing" thing.)

Any benzo will help prevent seizures, not just Klonopin, but be careful you don't pick up a habit of those, cause they're nasty to get off.

I felt confused as to why I was in Hospital after my first seizure but I felt good. My second seizure the paramedic in the Ambulance was hot so it was a great trip to Hospital.

I thought Klonopin was the main Benzo for preventing seizures?