GPCR activation by electromagnetic radiation stimulation

[gladiolus]

Hi,
does anyone know of any research done into stimulating G protein coupled receptors with frequency packets of electromagnetic radiation to change the GPCR inactive protein conformation into an active conformation, thereby binding G-proteins (intercellularly) to the receptor and producing cell signalling events?
Interested, even if the results show a negative...

 

[sekio]

That's not how GPCRs really work. They usually need a ligand to bind to activate. Radio energy is not enough to knock the protien into the right shape and keep it there.

"frequency packets of electromagnetic radiation"? Really? Radio waves, you mean? Look up transcranial magnetic stimulation, maybe.

I think most of the downstream effects of TMS and stuff come from induced currents, not from direct interaction with protiens.

 

[endotropic]

Hi,
does anyone know of any research done into stimulating G protein coupled receptors with frequency packets of electromagnetic radiation to change the GPCR inactive protein conformation into an active conformation, thereby binding G-proteins (intercellularly) to the receptor and producing cell signalling events?
Interested, even if the results show a negative...

You should also keep in mind that GPCR activation UNCOUPLES the G-proteins from the receptor, allowing the G-proteins to move through the cell and interact with downstream signaling molecules. The GPCR and G-proteins are tightly coupled in the inactive state.

 

[gladiolus]

really, no secret Russian labs working on this idea?