Glowing colors from lorazepam ?

[Kdem]

One thing I've noticed about this benzo is that it stimulates the appetite in a way unlike that of any different benzo that I have taken.

In this country it is sometimes prescribed in cases of nausea caused by chemotherapy.

Does anyone know what mechanism could be in play ?

 

[endotropic]

Glowing colors and appetite stimulation? Does anyone know whether it has cannabinoid activity?

 

[Kdem]

Muscimol functions primarily as a direct agonist at GABA-A, while the z-drugs are positive allosteric modulators at GABAA, like the benzodiazepines, but they are more selective (I want to say for the alpha1 subunit, but I know elsewhere as well). I'm not sure if activity outside of this function as a PAM has even been investigated. Basically, we don't know what underlies the hallucinatory effects, and researchers aren't particularly eager to throw resources at the problem.

ebola

I'm curious, where else are they more selective ?

 

[Kdem]

After switching between lorazepam and clonazepam I wonder if indeed lorazepam doesn't have some acetylcholine-specfific action. Some anticholinergic action ?

Can someone translate this for me ? http://www.ncbi.nlm.nih.gov/pubmed/22333515
The article discusses anticholinergic effects of different benzodiazepines. Ascending order (IC50) values ... I(K)(ACh) medazepam ... chlordiazepoxide Most anticholinergic to least anticholinergic, or least anticholinergic to most anticholinergic ?

After briefly switching back from lorazepam to clonazepam, I'm getting a dry mouth - which suggests an anticholinergic effect - but clonazepam usually causes more saliva production ! As if lorazepam has 'cholinergic' properties, but maybe that's nonsense ?