chicken hoagie
Bluelighter
- Joined
- Jan 1, 2014
- Messages
- 359
What is your take on neurotoxicity associated with GHB? Or moreso, the prodrug 1,4-Butanediol. Obviously the intermediate metabolites of 1,4-B are toxic just as ethanol produces aldehyde metabolites. But from what I have read, GHB alone causes neurotoxic effects in the hippocampus and prefrontal cortex, with a reverse dose-response..That is to say, lesser doses create more neurotoxicity and higher doses creating less neurotoxicity. It is purported to be mediated through the GHB receptor's agonism.
Does anyone have experience with these substances and can possibly support or mitigate these claims?
Does anyone have experience with these substances and can possibly support or mitigate these claims?