Misc GHB and Amitriptyline

[Synaps3]

Do you think this combo would be safe? I know it's probably fine, but I just want to make sure. Apparently amitriptyline has some weak DRI action. Could the GHB combined with this lead to excessive dopamine?

 

[psynce of sound]

I'm unsure about the dopamine related question but I'd be concerned with the two both being CNS depressants in all likelihood.

If that is so then there could/would be issues with blood pressure and possibly breathing. So with that in mind I'd say no they aren't safe to combine.

Though I am making an educated guess and hopefully someone with better knowledge will be able to give a more concise answer.

Good luck, stay safe and peace.

 

[Speed King]

^^ as stated above, worst case scenario, very possible od from the relatively strong CNS depressant effects of the amitriptyline. Not advised. Bad combo.

 

[Synaps3]

I'm not concerned with the depressant effects of amitriptyline as I've used it with alcohol before without a problem and it's not that sedating. I do not intend to combine these at the same time to get high. It just so happens that I'm prescribed ami and I want to know if it's OK to have in my system with the GHB. The only thing that concerns me is the effect on dopamine. Will there be a buildup of too much dopamine from this? (amitriptyline is a weak dopamine reuptake inhibitor.)

I know it's probably not at all a problem, but I just want to be sure.

 

[Synaps3]

Anyone have an answer?

I need to know if the GHB will interact causing any sort of effects such as serotonin syndrome (or dopamine syndrome if there is such a thing).

 

[EnlightenedOne1]

In my opinion and experience you will be fine assuming you understand the strict dynamics and approach towards ghb dosing... In reality, ghb doesnt have a pronounced dopamine rebound like gbl which i believe that gbl should NEVER be consumed without the conversion to naGHB. Just start small and gauge effects and remember to allow 2
Hours between your first and second dose.. Respiratory depression should not be a concern with this combo... GHB if taken correctly and learning your
Dosing protocol is one of the safest drugs but there also a fine line between safe and disaster...So many factors to consider
From the concentration of the GHB to body weight and what othter substances are floating in your system...
I only recommend GHB for sole use, comedowns, deep sleep flood doses
I.e. 4-6 gram doages before bed, and taken in conjunction with CNS stimulants... My favorite combo is Ghb and adderall IR

 

[Synaps3]

Thanks for the detailed response. Yeah, I've experienced the rebound on GBL even after only 1.5 days of chronic use. I never use GBL anymore and I would only use GHB twice per day max.