Hi community sorry if this question has been addressed already but I couldn't quite find the answer I was looking for. My question is why do I see some people say that they take ibuprofen to help the gabbapentin. What does ibuprofen to if taken with the gabbapentin? Thank you in advance for any help on this topic.
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BDD Moderators: Keif’ Richards | negrogesic
Gabbapentin and Ibuprofen
- Thread starter Bnebel15
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They do not interact at all pharmacologically, so any benefit would be a combination of analgesia or psychlogical... to my knowledge.
They likely potentiate each other's analgesia... otherwise I have no idea.
They likely potentiate each other's analgesia... otherwise I have no idea.
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Hey @Bnebel15
I think the confusion here is that the drug in question is not actually Ibuprofen (Advil) but Naproxen (Aleve). These are both OTC analgesics with similar action but different mechanisms. There is some data out there that indicates Naproxen can boost the effects of both Gabapentin (Neurontin) and Pregabalin (Lyrica), which I'm sure other readers will find interesting, given the huge difference in pharmacokinetics between these two drugs. Anyway, there is a lot of reported experience others have had positively in taking Naproxen with Gabapentinoids.
Whatever is causing the increase in potency seems to be unknown, but it definitely seems to be present. Here is the article I'm using as reference. It seems to indicate a 10:1 ratio of Gabapentin/Naproxen as favorable.
Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia - PubMed
These data suggest that gabapentin + naproxen and pregabalin + naproxen can interact synergistically or additively to reverse thermal hyperalgesia associated with peripheral inflammation. Therefore, the use of gabapentin or pregabalin in low-dose combinations with naproxen may afford therapeutic...
pubmed.ncbi.nlm.nih.gov