Swimmingdancer
Bluelight Crew
- Joined
- Jan 2, 2012
- Messages
- 5,433
Sorry if there are threads on this already, but I couldn't find anything that fully/properly answers my questions. Feel free to point me to other relevant threads.
Is the mechanism(s) of action of gabapentin known/understood? I have done quite a bit of reading on it and there are studies saying it doesn't bind to GABA receptors, but it sure feels like it affects GABA in some way.
How common is physiological dependence and what are withdrawals (if any) like? Obviously this would vary a lot from person to person and depend on dosage and duration of use, but there have been a few very vocal people on here saying it cause severe incredibly long withdrawals, far worse than benzos, after only a short time of use, which contradicts everything my doctors believe about it and so I'm looking for a balance of different people's experiences with it to get a more general picture.
Is there cross-tolerance and cross-dependence from gabapentin and benzodiazepines?
*Also please note that while pregabalin is considered a pro-drug for gabapentin, I am more interested in people's experiences with normal therapeutic doses of gabapentin than high doses of pregabalin when it comes to withdrawals, as they would be more relevant to my situation. Also for those who were taking gabapentin to get off benzos or opioids what makes you believe that your withdrawals were solely the result of the gabapentin, (if you do believe that)?
Is the mechanism(s) of action of gabapentin known/understood? I have done quite a bit of reading on it and there are studies saying it doesn't bind to GABA receptors, but it sure feels like it affects GABA in some way.
How common is physiological dependence and what are withdrawals (if any) like? Obviously this would vary a lot from person to person and depend on dosage and duration of use, but there have been a few very vocal people on here saying it cause severe incredibly long withdrawals, far worse than benzos, after only a short time of use, which contradicts everything my doctors believe about it and so I'm looking for a balance of different people's experiences with it to get a more general picture.
Is there cross-tolerance and cross-dependence from gabapentin and benzodiazepines?
*Also please note that while pregabalin is considered a pro-drug for gabapentin, I am more interested in people's experiences with normal therapeutic doses of gabapentin than high doses of pregabalin when it comes to withdrawals, as they would be more relevant to my situation. Also for those who were taking gabapentin to get off benzos or opioids what makes you believe that your withdrawals were solely the result of the gabapentin, (if you do believe that)?