As has been mentioned, foxy (5-MeO-DiPT) is basically a classic psychedelic. It does not release any monoamines (including serotonin), it agonizes them, ie, fits into the receptor sites and mimics serotonin and whatever else the molecule has an affinity for. As such, it's pretty safe to use even weekly as it does not deplete your neurotransmitters, but the thing about all psychedelics is that if you use them too often, they lose that special magic. It goes beyond just acute tolerance, which dissipates in about a week. Part of the magic of psychedelics is that they throw you so far off baseline that you experience life in a completely novel way. This leads to profound feelings and even realizations depending on the trip. If you start tripping weekly, it will start to feel more "normal", so some of the impact will be lost. I've tripped countless hundreds of times, much of it in a couple of years of extreme overuse back in 2006-2007, and I can say that although my trips are still great, even when I do it weekly (usually in the summer I trip weekly or at least every other week), I am very rarely able to reach those initial places I used to get back before I had tripped so much. I am simply much more used to the psychedelic state. If you want to keep the full level of magic, I'd say you should only trip very occasionally, when the time is right.
I don't really regret tripping so much, I mean psychedelics still bring value into my life (now that I use them anywhere from once a month to once a week, when I did it more often it was pointless and resulted in permanent tolerance after a couple of years). But sometimes it would be nice to be able to get as far out as I used to.
