You need an item called Thor's Cancer Hammer to crush them. Nothing else is capable. They keep it in the pardue pharma lab to make sure no one can defeat the time release on any of the new OP's. I'd suggest you raise an army, knock down the walls, and take the hammer from them! Every guy there is at least level 90 though, do not underestimate them. I've heard they all have level 10 "intoxicate" spells, if you get hit with it, *bam* you're drooling all over yourself for the next couple of days. The trick is, if you get the hammer, it makes you immune unless you snort the pills you crush with it.... pfffft
Seriously, you resurrected a year old thread to ask how to crush these pills after you have tried crushing one? Perhaps you could search around and find the oxycontin megathread, I'll bet you ran across it before you found this one. There is a method on there that allows you to snort them, but I've heard it's gross, takes a lot of work, and the long term consequences of microwaving plastic pills to snort is unknown, but likely not good.