Just because they're both natural plants, doesn't make them both safe for someone with a heart problem to use in any dosage. This thread has really gone way off course - it's more about minimum-impact highs now, which are a fine idea for consenting adults in good health. However, please keep in mind that we're discussing;
a) a 17-year-old teenage girl
b) who has a congenital heart problem
c) which requires 3-monthly medical checkups
d) who drinks alcohol, smokes tobacco and cannabis
e) and has never tried E before
Personally I believe that she can have equally as good a time using recreational drugs that she knows she is comfortable with. Is she just persistently seeking the unattainable because this is the nature of teenagers to want to continually test the limits applied by their parents/peers? Alcohol and cannabis can contribute to an almighty altering of consciousness, if used in the right way, and they have pretty predictable effects on the body.
Quite simply there are very few people here who could give you reliable advice on taking illicit drugs in her condition. The information doesn't really exist - because funding doesn't exist for studies like this, because nobody in their right mind would take E when they have had a heart transplant and are on medication to stop it being rejected by their body...
But, clearly the existence of this thread indicates how persistent (i.e., "she has read the thread but still wants to peak") she is being with regard to this query. So, I will close by observing that applying a small amount of drug knowledge to a situation that requires a large amount of medical knowledge, is NOT harm reduction. It's also not harm minimisation to repeatedly ask the same question (with the drug name interchanged) in the face of the same answers every time, particularly in this instance. I applaud you for trying to help her out by seeking all the information, but she really needs to remember what is at risk, and reconsider the position of reponsibility she is putting you in. If I was you, I would say "what am I, your doctor?" and handball her straight to her specialist to do some personal real research into the matter, rather than waiting for someone to present her with a pill and some info, and absolve her of responsibility for her actions.
BigTrancer