asecin
Bluelighter
- Joined
- Apr 13, 2005
- Messages
- 1,725
Guys, aniractam has POWERFUL sertonergic and dopamiergic effects. this is most likely the cause for the depression.
http://www.sciencedirect.com/science/article/pii/S0006899301029390
http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2002.tb00216.x/pdf
No I haven't tried any selevtive racetams yet. I am very true into nootropics.
Originally Posted by Ligaturd
Aniracetams metabolite N-Anisoyl-GABA is a gaba receptor agonist (not sure about selectivity) but it modulates glutamate levels. It simultaneously has nootropic effects and anxiolytic effects. That combined with Coluracetam pretty much temporarily got rid of my anxiety and depression when I was in the midst of a psychotic break. It's definitely in my top 3 racetams but no, it isn't an antagonist.
[/B]^Asecin, Tianeptine will modulate the AMPA and NMDA glutamate receptors for as the duration of the drug lasts. It would always work on these channels for however long this drug is in your body. It's pharmacology will never change: it will always work on the AMPA and NMDA ionophere.
And tianeptine's effects on the MOR are insignificant on its therapeutic and nootropic effects; you actually need quite large/many times the therapeutic dose to even feel the mu opioid effects. It's serotonergic effects are weak as well. It has much more pronounced effects on dopamine receptors and ionotropic glutamate receptors.
I'm just kind of mad with got stuck with this one. Amineptine would have been better...
Asecin...
I doubt it is because of the glutamate that aniracetam and tianeptine feel familiar too you.
It is more likely due to the fact that both tianeptine and aniracetam both have profound serotonergic and dopaminergic effects in the brain.
"aniractam has POWERFUL sertonergic and dopamiergic effects. this is most likely the cause for the depression" so it will cause rebound depression after stopping it for whatever reason? well, thats not very useful, is it
about tianeptine you say this " It's serotonergic effects are weak as well" but then you say this "It is more likely due to the fact that both tianeptine and aniracetam both have profound serotonergic effect...." so you say it has little value to serotonin but then say it has a lot of value comparison to aniracetam, im confused.
and about its mu opioid effect you seem to think in very high doses it might have such effect which i think again you are unsure of this as i believe i have felt that specific effect at lower standard dosage.
what i want to help figure out and prevent its MOR tolerance and withdrawl, likely "Another long-term adaptation to opioid use can be upregulation of glutamate and other pathways in the brain which can exert an opioid-opposing effect" using something for glutamate modification of sorts?
i really wish to find the best most reliable tolerance and withdrawl MOR prevention pill.