aced126
Bluelighter
- Joined
- May 18, 2015
- Messages
- 1,047
Venlafaxine is an SNDRI..
You are correct about your last point. That is a hell of a lot of norepinephrine :/ I wouldn't want to be on that combo every day. It sounds fun to combine recreationally, though.
Propranolol or any beta blocker would only make the sweating worse. It's actually a common side effect of them. By blocking the beta adrenergic receptors, it leaves the alpha adrenergic receptors entirely unopposed, and they are free to be activated by norepinphrine and epinephrine. This isn't a good thing to recommend. The alpha blockers or alpha 2 agonists would be work.
The concentration of NE or E that binds to a receptor is negligible to the concentration of free, unbound molecules. In other words, blocking a ligand from binding to a receptor will barely result in more free ligands to activate other exposed receptors, in most cases. The phenomenon where this does occur is called ligand depletion, and it would only occur when you're dealing with an extremely potent ligand (probably with sub-picomolar affinity at least).