brokedownpalace10
Bluelighter
- Joined
- Jun 30, 2022
- Messages
- 1,540
[https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15865#![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
~:text=Δ8-THC is a,plausible mechanisms that may contribute](https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15865#:~:text=Δ8-THC is a,plausible mechanisms that may contribute).
"Putting aside the uncertainty in some in vitro results, it appears that Δ8-THC has a lower potency then Δ9-THC at the human CB1 receptor and a similar potency at the human CB2 receptor. Because cannabis users titrate the dose to the effect they want, equivalent CB1 receptor activation is likely to occur in the real world regardless of which cannabinoid is used. However, at a dose that produces equivalent CB1 receptor activation, Δ8-THC will likely produce greater CB2 receptor activation than Δ9-THC."
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So, people taking rather large doses of D8 to get high are maybe downregulating the CB2 receptors quite a bit.
This would and could hold true for any products which are D8 at the core, which I think is all of them.
The CB2 receptor is the peripheral receptor. Has a big role in inflammation. You could look at it as the "body" receptor and the CB1 as the "brain" receptor.
So... wouldn't much greater CB2 receptor downregulation cause much more in the way of tolerance and/or physical symptoms during withdrawal?
~:text=Δ8-THC is a,plausible mechanisms that may contribute](https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15865#:~:text=Δ8-THC is a,plausible mechanisms that may contribute)."Putting aside the uncertainty in some in vitro results, it appears that Δ8-THC has a lower potency then Δ9-THC at the human CB1 receptor and a similar potency at the human CB2 receptor. Because cannabis users titrate the dose to the effect they want, equivalent CB1 receptor activation is likely to occur in the real world regardless of which cannabinoid is used. However, at a dose that produces equivalent CB1 receptor activation, Δ8-THC will likely produce greater CB2 receptor activation than Δ9-THC."
********************************
So, people taking rather large doses of D8 to get high are maybe downregulating the CB2 receptors quite a bit.
This would and could hold true for any products which are D8 at the core, which I think is all of them.
The CB2 receptor is the peripheral receptor. Has a big role in inflammation. You could look at it as the "body" receptor and the CB1 as the "brain" receptor.
So... wouldn't much greater CB2 receptor downregulation cause much more in the way of tolerance and/or physical symptoms during withdrawal?