I've been reading a alot on here about MDMA and SSRI's, mainly effexor. I've been on 75mg of effexor for over 10 years and wanted to try MDMA. There were mixed reviews. I concluded that there was really no harm (serotonin syndrome is NOT an issue), just that it will not effect me. Well this showed to be very true! Left the bar early and came home because I felt absolutely nothing. Very Sad As far as not taking the effexor for a few day was totally not an option for me, the withdrawal is not worth it